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Physical Review LettersVolume 78, Issue 9, 3 March 1997, Pages 1667-1670

Single molecule detection using surface-enhanced raman scattering (SERS)(Article)

  • Kneipp, K.,
  • Wang, Y.,
  • Kneipp, H.,
  • Perelman, L.T.,
  • Itzkan, I.,
  • Dasari, R.R.,
  • Feld, M.S.
  • aGeorge R. Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, MA, 02139, United States
  • bDepartment of Physics, Technical University of Berlin, Berlin, D-10623, Germany

Abstract

By exploiting the extremely large effective cross sections (10−17-10−16 cm2/molecule) available from surface-enhanced Raman scattering (SERS), we achieved the first observation of single molecule Raman scattering. Measured spectra of a single crystal violet molecule in aqueous colloidal silver solution using one second collection time and about 2 × 105W/cm2 nonresonant near-infrared excitation show a clear “fingerprint” of its Raman features between 700 and 1700cm−1. Spectra observed in a time sequence for an average of 0.6 dye molecule in the probed volume exhibited the expected Poisson distribution for actually measuring 0, 1, 2, or 3 molecules. © 1997 The American Physical Society.

Funding details

Funding numberFunding sponsorAcronymFunding opportunities
Deutsche ForschungsgemeinschaftDFGSee opportunities by DFG

  • 1

    ( GIFML, Moscow, 1959 ). The work was carried out at the NIH-supported MIT Laser Biomedical Research Center and the NSF-supported MIT Laser Research Facility. One of us (K. K.) is grateful to the Deutsche Forschungsgemeinschaft for the award of the Heisenberg Fellowship.

  • ISSN: 00319007
  • Source Type: Journal
  • Original language: English
  • DOI: 10.1103/PhysRevLett.78.1667
  • Document Type: Article


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