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Virchows ArchivVolume 451, Issue 4, October 2007, Pages 757-762

TNM staging of midgut and hindgut (neuro) endocrine tumors: A consensus proposal including a grading system(Article)(Open Access)

  • Rindi, G.,
  • Klöppel, G.,
  • Couvelard, A.,
  • Komminoth, P.,
  • Körner, M.,
  • Lopes, J.M.,
  • McNicol, A.-M.,
  • Nilsson, O.,
  • Perren, A.,
  • Scarpa, A.,
  • Scoazec, J.-Y.,
  • Wiedenmann, B.
  • View Correspondence (jump link)
  • aDepartment of Pathology, University of Parma, Parma, Italy
  • bDepartment of Pathology, University of Kiel, Kiel, Germany
  • cDepartment of Pathology, Hôpital Beaujon, Clichy, France
  • dDepartment of Pathology, Stadspital Triemli, Zürich, Switzerland
  • eDepartment of Pathology, University of Bern, Bern, Switzerland
  • fDepartment of Pathology, Porto Medical School and IPATIMUP, University of Porto, Porto, Portugal
  • gDepartment of Pathology, Glasgow Royal Infirmary, Glasgow, United Kingdom
  • hDepartment of Pathology, Gothenborg University, Gothenborg, Sweden
  • iDepartment of Pathology, Klinikum Rechts der Isar, Munich, Germany
  • jDepartment of Pathology, University of Verona, Verona, Italy
  • kDepartment of Pathology, University of Lyon, Lyon, France
  • lDepartment of Internal Medicine, Campus Virchow Klinikum, Berlin, Germany
  • mDipartimento di Patologia e Medicina di Laboratorio, Sezione di Anatomia Patologica, Università di Parma, Via Gramsci, 14, Parma 43100, Italy

Abstract

Criteria for the staging and grading of neuroendocrine tumors (NETs) of midgut and hindgut origin were established at the second Consensus Conference in Frascati (Rome) organized by the European Neuroendocrine Tumor Society (ENETS). The proposed tumor-node-metastasis (TNM) classifications are based on the recently published ENETS Guidelines for the Diagnosis and Treatment of gastroenteropancreatic NETs and follow our previous proposal for foregut tumors. The new TNM classifications for NETs of the ileum, appendix, colon, and rectum, and the grading system were designed, discussed, and consensually approved by all conference participants. These proposals need to be validated and are meant to help clinicians in the stratification, treatment and follow-up of patients. © 2007 Springer-Verlag.

Author keywords

AppendixColonGradingIleumKi-67 indexMitotic indexNeuroendocrine tumorsRectumStagingTNM

Indexed keywords

EMTREE medical terms:appendixappendix cancerarticlecancer diagnosiscancer stagingcoloncolon cancerfollow uphindguthumanileumileum cancerintestinemidgutneuroendocrine tumorpriority journalrectumrectum cancer
MeSH:Appendiceal NeoplasmsCarcinoma, NeuroendocrineCell ProliferationColonic NeoplasmsEuropeGuidelines as TopicHumansIleal NeoplasmsLymph NodesLymphatic MetastasisNeoplasm StagingRectal Neoplasms
  • ISSN: 09456317
  • CODEN: VARCE
  • Source Type: Journal
  • Original language: English
  • DOI: 10.1007/s00428-007-0452-1
  • PubMed ID: 17674042
  • Document Type: Article

  Rindi, G.; Dipartimento di Patologia e Medicina di Laboratorio, Sezione di Anatomia Patologica, Università di Parma, Via Gramsci, 14, Italy;
© Copyright 2008 Elsevier B.V., All rights reserved. © MEDLINE® is the source for the MeSH terms of this document.

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