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Angewandte Chemie - International EditionVolume 47, Issue 9, 15 February 2008, Pages 1658-1661

Tip-enhanced Raman spectroscopy of single RNA strands: Towards a novel direct-sequencing method(Article)

  • ISAS - Institute for Analytical Sciences, Bunsen-Kirchhoff-Strasse 11, 44139 Dortmund, Germany

Abstract

(Figure Presented) Walking the strand: Tip-enhanced Raman scattering (TERS) with precision probe positioning has been used to obtain high-quality Raman spectra of the nucleobases in a single RNA strand (see picture: foreground Raman spectrum, background atomic-force microscope tip positioned over the RNA strand). This procedure represents the first step towards direct and label-free single-biomolecule sequencing. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

Author keywords

Raman spectroscopyRNAScanning probe microscopySequencingSurface analysis

Indexed keywords

Engineering controlled terms:Architectural acousticsAtomic spectroscopyNucleic acidsRaman spectroscopyRNA
Engineering uncontrolled terms:Enhanced Raman scatteringHigh-qualityLabel-freeNucleobasesRAMAN spectrumScanning probe microscopySequencingSurface analysisTip-enhanced Raman Spectroscopy
Engineering main heading:Raman scattering
EMTREE drug terms:RNA
EMTREE medical terms:articlemethodologyRaman spectrometrysequence analysis
MeSH:RNASequence Analysis, RNASpectrum Analysis, Raman

Chemicals and CAS Registry Numbers:

RNA, 63231-63-0;

RNA, 63231-63-0

  • ISSN: 14337851
  • CODEN: ACIEA
  • Source Type: Journal
  • Original language: English
  • DOI: 10.1002/anie.200704054
  • PubMed ID: 18188855
  • Document Type: Article

  Bailo, E.; ISAS - Institute for Analytical Sciences, Bunsen-Kirchhoff-Strasse 11, Germany;
© Copyright 2008 Elsevier B.V., All rights reserved.

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