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Applied Physics LettersVolume 96, Issue 21, 24 May 2010, Article number 213701

Single DNA molecule detection in an optical trap using surface-enhanced Raman scattering(Article)

  • aICFO-Institut de Cìncies Fotniques, Mediterranean Technology Park, 08860 Castelldefels, Barcelona, Spain
  • bDepartament de Geǹtica i de Microbiologia, Universitat Autonoma Barcelona, 08193 Barcelona, Spain
  • cInstitucio Catalana de Recerca i Estudis Avancats (ICREA), 08010 Barcelona, Spain

Abstract

Raman spectra from single DNA molecules in their natural aqueous environment are presented. A DNA molecule that is anchored between two optically trapped dielectric beads is suspended in a solution with nanosized silver colloid particles. The nonspecific binding of the metal to the DNA enhances the Raman scattering that is excited by a near-infrared beam. A Raman spectrum is first recorded followed by a force-extension curve that verifies the presence of a single DNA molecule. © 2010 American Institute of Physics.

Indexed keywords

Engineering uncontrolled termsAqueous environmentDNA moleculesForce-extension curvesNano-sized silver colloidsNear InfraredNon-specific bindingOptical trapRaman spectraRaman SpectrumSingle DNA moleculesSurface enhanced Raman scattering
Engineering controlled terms:GenesMoleculesRaman scatteringRaman spectroscopySilver
Engineering main heading:DNA
  • ISSN: 00036951
  • CODEN: APPLA
  • Source Type: Journal
  • Original language: English
  • DOI: 10.1063/1.3431628
  • Document Type: Article

  Petrov, D.; ICFO-Institut de Cìncies Fotniques, Mediterranean Technology Park, 08860 Castelldefels, Spain;
© Copyright 2010 Elsevier B.V., All rights reserved.

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