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ScienceVolume 331, Issue 6022, 11 March 2011, Pages 1319-1321

A bacterial protein targets the BAHD1 chromatin complex to stimulate type III interferon response(Article)

  • Lebreton, A.,
  • Lakisic, G.,
  • Job, V.,
  • Fritsch, L.,
  • Tham, T.N.,
  • Camejo, A.,
  • Matteï, P.-J.,
  • Regnault, B.,
  • Nahori, M.-A.,
  • Cabanes, D.,
  • Gautreau, A.,
  • Ait-Si-Ali, S.,
  • Dessen, A.,
  • Cossart, P.,
  • Bierne, H.
  • View Correspondence (jump link)
  • aInstitut Pasteur, Unité des Interactions Bactéries Cellules, Paris F-75015, France
  • bInserm, U604, Paris F-75015, France
  • cINRA, USC2020, Paris F-75015, France
  • dCNRS UPR3082, Laboratoire d'Enzymologie et de Biochimie Structurales, Gif-sur-Yvette F-91198, France
  • eInstitut de Biologie Structurale, Bacterial Pathogenesis Group, UMR 5075 (CNRS/CEA/UJF), Grenoble F-38027, France
  • fCNRS UMR7216, Université Paris Diderot-Paris 7, Paris F-75013, France
  • gInstitute for Molecular and Cellular Biology, Porto 4150, Portugal
  • hInstitut Pasteur, Génopole, Paris F-75015, France

Abstract

Intracellular pathogens such as Listeria monocytogenes subvert cellular functions through the interaction of bacterial effectors with host components. Here we found that a secreted listerial virulence factor, LntA, could target the chromatin repressor BAHD1 in the host cell nucleus to activate interferon (IFN)-stimulated genes (ISGs). IFN-l expression was induced in response to infection of epithelial cells with bacteria lacking LntA; however, the BAHD1-chromatin associated complex repressed downstream ISGs. In contrast, in cells infected with lntA-expressing bacteria, LntA prevented BAHD1 recruitment to ISGs and stimulated their expression. Murine listeriosis decreased in BAHD1+/- mice or when lntA was constitutively expressed. Thus, the LntA-BAHD1 interplay may modulate IFN-λ-mediated immune response to control bacterial colonization of the host.

Indexed keywords

EMTREE drug terms:bacterial proteingamma interferonprotein bahd1unclassified drugvirulence factor
GEOBASE Subject Index:bacteriumcolonizationgene expressiongenetic analysisimmune responsepathogenproteinrodentvirulence
EMTREE medical terms:animal experimentanimal modelanimal tissuearticlechromatin structurecontrolled studygene activationhumanhuman cellimmune responseListeria monocytogeneslisteriosismousenonhumanpriority journalprotein targeting
Species Index:Bacteria (microorganisms)Listeria monocytogenesMurinaeMus

Chemicals and CAS Registry Numbers:

gamma interferon, 82115-62-6

  • ISSN: 00368075
  • CODEN: SCIEA
  • Source Type: Journal
  • Original language: English
  • DOI: 10.1126/science.1200120
  • Document Type: Article
  • Publisher: American Association for the Advancement of Science

  Cossart, P.; Institut Pasteur, Unité des Interactions Bactéries Cellules, France;
© Copyright 2018 Elsevier B.V., All rights reserved.

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