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Environmental Toxicology and PharmacologyVolume 36, Issue 3, November 2013, Pages 903-912

Effects of oxytetracycline and amoxicillin on development and biomarkers activities of zebrafish (Danio rerio)(Article)

  • aDepartment of Biology and CESAM, University of Aveiro Portugal, Campus Universitario de Santiago, Universidade de Aveiro, 3810-193 Aveiro, Portugal
  • bAquaculture and Aquatic Resources Management, Asian Institute of Technology, P.O. Box 4, Klong Luang, Pathumthani 12120, Thailand

Abstract

Antibiotics have been widely used in human and veterinary medicine to treat or prevent diseases. Residues of antibiotics have been found in aquatic environments, but their effects on fish have been not properly investigated. This work aimed to assess the sub-lethal effects of oxytetracycline and amoxicillin on zebrafish development and biomarkers. Embryos and adults were exposed during 96. h to amoxicillin and oxytetracycline following OECD guidelines. Tissues of adults and pools of embryos were used for catalase, glutathione-S-transferases and lactate dehydrogenase determinations. Amoxicillin caused premature hatching (48h-EC50. =. 132.4. mg/l) whereas oxytetracycline cause delayed hatching of embryos (72h-EC50. =. 127.6. mg/l). Moreover, both antibiotics inhibited catalase and induced glutathione-S-transferases in zebrafish adults. However, only oxytetracycline induced lactate dehydrogenase. Short-term effects of antibiotics were observed at high doses (mg/l) indicating that physiological impairment in fish populations is unlike to occur. However, effects of chronic exposures to low doses of ABs must be investigated. © 2013 Elsevier B.V.

Author keywords

AntibioticsCatalaseGlutathione-S-transferasesHatchingLactate dehydrogenasePharmaceuticals

Indexed keywords

EMTREE drug terms:amoxicillinbiological markercatalaseglutathione transferaselactate dehydrogenaseoxytetracycline
EMTREE medical terms:adult animalanimal embryoanimal experimentanimal tissuearticledevelopmental toxicitydrug effectembryoembryo developmentenzyme assayenzyme inductionenzyme inhibitionexposurehatchingnonhumanpriority journalzebra fish
Medline keywords:AntibioticsCatalaseGlutathione-S-transferasesHatchingLactate dehydrogenasePharmaceuticals
MeSH:AmoxicillinAnimalsAnti-Bacterial AgentsBiological MarkersCatalaseDose-Response Relationship, DrugEmbryo, NonmammalianEmbryonic DevelopmentGlutathione TransferaseGrowthL-Lactate DehydrogenaseLarvaOvumOxytetracyclineWater Pollutants, ChemicalZebrafish

Chemicals and CAS Registry Numbers:

amoxicillin, 26787-78-0, 34642-77-8, 61336-70-7; catalase, 9001-05-2; glutathione transferase, 50812-37-8; lactate dehydrogenase, 9001-60-9; oxytetracycline, 2058-46-0, 56761-42-3, 79-57-2

Manufacturers:

Drug manufacturer:

Sigma Aldrich

Funding details

Funding sponsor Funding number Acronym
Universidade de Aveiro
Fundação para a Ciência e a Tecnologia
See opportunities		SFRH/BD/62605/2009,SFRH/BPD/31752/2006,SFRH/BPD/62561/2009
Fundação para a Ciência e a Tecnologia
See opportunities

  • 1

    Authors acknowledge Fundação para Ciência e Tecnologia (FCT – Portugal) by the financial support through the grants SFRH/BPD/31752/2006 (Inês Domingues), SFRH/BPD/62561/2009 (Jessica C.L. Ladewig) and SFRH/BD/62605/2009 (Rhaul Oliveira) and University of Aveiro. Appendix A

  • ISSN: 13826689
  • CODEN: ETOPF
  • Source Type: Journal
  • Original language: English
  • DOI: 10.1016/j.etap.2013.07.019
  • PubMed ID: 24008007
  • Document Type: Article

  Oliveira, R.; Department of Biology and CESAM, University of Aveiro Portugal, Campus Universitario de Santiago, Universidade de Aveiro, Portugal;
© Copyright 2013 Elsevier B.V., All rights reserved.

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