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Journal of Biological ChemistryVolume 288, Issue 51, 20 December 2013, Pages 36285-36301

Several Cis-regulatory Elements Control mRNA Stability, Translation Efficiency, and Expression Pattern of Prrxl1(Paired Related Homeobox Protein-like 1)(Article)(Open Access)

  • aDepartamento de Biologia Experimental, Faculdade de Medicina do Porto, Universidade do Porto, Porto 4200-319, Portugal
  • bInstituto de Biologia Molecular e Celular, Universidade do Porto, Porto 4150, Portugal
  • cCABD (Consejo Superior de Investigaciones Científicas-UPO-Junta de Andalucía), Seville 41013, Spain

Abstract

Background: The mechanisms that control the Prrxl1 expression are poorly understood. Results: Several regulatory elements present in Prrxl1 alternative promoters are functionally characterized, including a binding motif for Phox2b required for Prrxl1 expression in visceral sensory neurons. Conclusion: We define diverse regulatory modules, which control the spatiotemporal expression of Prrxl1 in nociceptive neurons. Significance: A new mechanism involved in the ganglion specific action of Prrxl1 is described. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.

Indexed keywords

Engineering uncontrolled termsBinding motifCis-regulatory elementsExpression patternsmRNA stabilityNew mechanismsRegulatory elementsSensory neurons
Engineering controlled terms:BiochemistryBiology
Engineering main heading:Neurons
EMTREE drug terms:messenger RNAPhox2b proteinPrrxl1 proteintranscription factorunclassified drug
EMTREE medical terms:5' untranslated regionanimal experimentanimal tissuearticlebinding sitecontrolled studydrgx geneembryofacial nervegangliongenegene expressiongene expression regulationglossopharyngeal ganglionhumanhuman cellin vivo studymousenociceptionnonhumanpriority journalpromoter regionprotein bindingprotein expressionprotein motifPrrxl1 generegulatory sequenceRNA stabilityRNA translationsensory nerve cellTATA boxvagal cranial gangliavagal cranial ganglionvisceral sensory nerve cellzebra fish
Medline keywords:5′-UTRAlternative PromotersGene RegulationNeurodevelopmentPainPhox2bPromotersPrrxl1Sensory NeuronsTranscription/Developmental Factors
MeSH:5' Untranslated RegionsAnimalsBase SequenceBinding SitesGene Expression Regulation, DevelopmentalHEK293 CellsHeLa CellsHomeodomain ProteinsHumansMiceMolecular Sequence DataNerve Tissue ProteinsNeuronsPC12 CellsProtein BiosynthesisRatsRNA StabilityRNA, MessengerTATA BoxTranscription FactorsTranscription, GeneticZebrafish
  • ISSN: 00219258
  • CODEN: JBCHA
  • Source Type: Journal
  • Original language: English
  • DOI: 10.1074/jbc.M113.491993
  • PubMed ID: 24214975
  • Document Type: Article

  Reguenga, C.; Departamento de Biologia Experimental, Faculdade de Medicina do Porto, Universidade do Porto, Portugal;
© Copyright 2014 Elsevier B.V., All rights reserved.

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