• Oliveira, C.,
• Pinheiro, H.,
• Figueiredo, J.,
• Seruca, R.,
• Carneiro, F.
• View Correspondence (jump link)

• ^aIpatimub-Inst. of Molecular Pathology and Immunology, Instituto Instituto de Investigação e Inovação em Saúde, University of Porto, Porto, Portugal
• ^bDepartment of Pathology and Oncology, Faculty of Medicine, University of Porto, Porto, Portugal
• ^cCentro Hospitalar S João, Porto, Portugal

Indexed keywords

Chemicals and CAS Registry Numbers:

uvomorulin, 112956-45-3

Funding details

• 1

  We searched PubMed with the terms “hereditary diffuse gastric cancer (HDGC)”, “early onset gastric cancer”, “familial gastric cancer”, “gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS)”, and “E-cadherin germline mutations” for articles in English published between Jan 1, 1998, and 30 June, 2014. We also searched our files, particularly for papers about gastric-cancer-associated syndromes and the pathology of HDGC. We generated the final reference list on the basis of originality and relevance to the broad scope of this Review. Contributors FC and CO contributed to the conceptual design, supervision, and preparation of the Review. CO, HP, JF, RS, and FC analysed and interpreted data. HP compiled all relevant references and tabulated data. All authors drafted the paper and read, commented on, and approved the final version before submission. Declaration of interests We declare that we have no competing interests. Acknowledgments We thank the Portuguese Foundation for Science and Technology (FCT), the Programa Operacional Temático Factores de Competitividade (COMPETE), and fundo Comunitário Europeu FEDER for funding the grant (FCT PTDC/SAU-GMG/110785/2009), and postdoctoral fellowships for HP (SFRH/BPD/79499/2011) and JF (SFRH/BPD/87705/2012). We also thank Mafalda Nobre for the design of the figures.