Skip Main Navigation Links Jump to Footer

Scopus Preview

Nature Cell BiologyVolume 17, Issue 5, 5 May 2015, Pages 615-626

TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors(Article)

  • Cebola, I.,
  • Rodríguez-Seguí, S.A.,
  • Cho, C.H.-H.,
  • Bessa, J.,
  • Rovira, M.,
  • Luengo, M.,
  • Chhatriwala, M.,
  • Berry, A.,
  • Ponsa-Cobas, J.,
  • Maestro, M.A.,
  • Jennings, R.E.,
  • Pasquali, L.,
  • Morán, I.,
  • Castro, N.,
  • Hanley, N.A.,
  • Gomez-Skarmeta, J.L.,
  • Vallier, L.,
  • Ferrer, J.
  • View Correspondence (jump link)
  • aDepartment of Medicine, Imperial College London, London, W12 0NN, United Kingdom
  • bGenomic Programming of Beta-cells Laboratory, Institut d'Investigacions August Pi I Sunyer (IDIBAPS), Barcelona, 08036, Spain
  • cCIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Barcelona, 08036, Spain
  • dLaboratorio de Fisiología y Biología Molecular, Departamento de Fisiología,Biología Molecular y Celular, Universidad de Buenos Aires, Buenos Aires, C1428EGA, Argentina
  • eWellcome Trust and MRC Stem Cells Centre, Department of Surgery, University of Cambridge, Cambridge, CB2 0SZ, United Kingdom
  • fInstituto de Biologia Molecular e Celular (IBMC), Porto, 4150-180, Portugal
  • gInstituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, 4200-135, Portugal
  • hCentro Andaluz de Biología del Desarrollo, Consejo Superior de Investigaciones Científicas, Universidad Pablo de Olavide, Sevilla, 41013, Spain
  • iWellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, United Kingdom
  • jCentre for Endocrinology and Diabetes, Institute of Human Development, University of Manchester, Manchester, M13 9PT, United Kingdom
  • kEndocrinology Department, Central Manchester University Hospitals NHS Foundation Trust, Manchester, M13 9WU, United Kingdom
  • lGenomics Research Center, Academia Sinica, Taipei, 115, Taiwan
  • mDivision of Endocrinology, Germans Trias i Pujol University Hospital and Research Institute, Josep Carreras Leukaemia Research Institute, Badalona, 08916, Spain

Abstract

The genomic regulatory programmes that underlie human organogenesis are poorly understood. Pancreas development, in particular, has pivotal implications for pancreatic regeneration, cancer and diabetes. We have now characterized the regulatory landscape of embryonic multipotent progenitor cells that give rise to all pancreatic epithelial lineages. Using human embryonic pancreas and embryonic-stem-cell-derived progenitors we identify stage-specific transcripts and associated enhancers, many of which are co-occupied by transcription factors that are essential for pancreas development. We further show that TEAD1, a Hippo signalling effector, is an integral component of the transcription factor combinatorial code of pancreatic progenitor enhancers. TEAD and its coactivator YAP activate key pancreatic signalling mediators and transcription factors, and regulate the expansion of pancreatic progenitors. This work therefore uncovers a central role for TEAD and YAP as signal-responsive regulators of multipotent pancreatic progenitors, and provides a resource for the study of embryonic development of the human pancreas. © 2015 Macmillan Publishers Limited.

Indexed keywords

EMTREE drug terms:regulator proteinTEA domain 1 proteinTEA domain proteintranscription factorunclassified drugYes associated proteinDNA binding proteinmessenger RNAnuclear proteinphosphoproteinsignal transducing adaptor proteinTEAD1 protein, humantranscription factorYAP1 (Yes-associated) protein, human
EMTREE medical terms:animal experimentArticlebinding sitecell expansioncell lineagecontrolled studydevelopmentembryoembryo developmentembryonic stem cellenhancer regionhumanhuman cellhuman tissuein vitro studyin vivo studymousemultipotent stem cellnonhumanpancreas cellpancreas developmentpriority journalprotein functionsignal transductionanimalbiologyC57BL mousecell culturecell differentiationcell proliferationembryologyembryonic stem cellgene expression regulationgene regulatory networkgenetic databasegeneticsmetabolismmultipotent stem cellorganogenesispancreasphenotypesignal transductiontimetransgenic animalzebra fish
MeSH:Adaptor Proteins, Signal TransducingAnimalsAnimals, Genetically ModifiedCell DifferentiationCell LineageCell ProliferationCells, CulturedComputational BiologyDatabases, GeneticDNA-Binding ProteinsEmbryonic Stem CellsGene Expression Regulation, DevelopmentalGene Regulatory NetworksHumansMice, Inbred C57BLMultipotent Stem CellsNuclear ProteinsOrganogenesisPancreasPhenotypePhosphoproteinsRNA, MessengerSignal TransductionTime FactorsTranscription FactorsZebrafish

Chemicals and CAS Registry Numbers:

Adaptor Proteins, Signal Transducing; DNA-Binding Proteins; Nuclear Proteins; Phosphoproteins; RNA, Messenger; TEAD1 protein, human; Transcription Factors; YAP1 (Yes-associated) protein, human

Funding details

Funding sponsor Funding number Acronym
Medical Research Council
See opportunities by MRC		G0800784MRC
Medical Research Council
See opportunities by MRC		G1100420MRC
Medical Research Council
See opportunities by MRC		MR/L02036X/1MRC
  • ISSN: 14657392
  • CODEN: NCBIF
  • Source Type: Journal
  • Original language: English
  • DOI: 10.1038/ncb3160
  • PubMed ID: 25915126
  • Document Type: Article
  • Publisher: Nature Publishing Group

  Ferrer, J.; Department of Medicine, Imperial College London, London, United Kingdom
© Copyright 2016 Elsevier B.V., All rights reserved.

Cited by 77 documents

Rosado-Olivieri, E.A. , Anderson, K. , Kenty, J.H.
YAP inhibition enhances the differentiation of functional stem cell-derived insulin-producing β cells
(2019) Nature Communications
Nagasawa, T. , Kawaguchi, M. , Yano, T.
Translocation of promoter-conserved hatching enzyme genes with intron-loss provides a new insight in the role of retrocopy during teleostean evolution
(2019) Scientific Reports
Vázquez-Marín, J. , Gutiérrez-Triana, J.A. , Almuedo-Castillo, M.
Yap1b, a divergent Yap/Taz family member, cooperates with yap1 in survival and morphogenesis via common transcriptional targets
(2019) Development (Cambridge)
View details of all 77 citations
Inform me when this document is cited in Scopus:
Set citation alert Set citation feed
{"topic":{"name":"Cells; Insulin; Pancreatic progenitors","id":567,"uri":"Topic/567","prominencePercentile":98.70993,"prominencePercentileString":"98.710","overallScholarlyOutput":0},"dig":"6b15812a36ceb74cadfe5e0e8f998965aa4a82137cebf6ee7d4846702918deda"}

SciVal Topic Prominence

Topic:
Prominence percentile: