• Mesquita, F.S.,
• Brito, C.,
• Mazon Moya, M.J.,
• Pinheiro, J.C.,
• Mostowy, S.,
• Cabanes, D.,
• Sousa, S.
• View Correspondence (jump link)

• ^aI3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal
• ^bGroup of Molecular Microbiology, IBMC, Universidade do Porto, Porto, Portugal
• ^cInstituto de Ciências Biomédicas Abel Salazar (ICBAS), Universidade do Porto, Porto, Portugal
• ^dSection of Microbiology, MRC Centre for Molecular Bacteriology and Infection (CMBI), Imperial College London, London, United Kingdom

Author keywords

Indexed keywords

Chemicals and CAS Registry Numbers:

myosin adenosine triphosphatase;

Actomyosin; Bacterial Proteins; Bacterial Toxins; endoplasmin; Membrane Glycoproteins; Molecular Chaperones; Pore Forming Cytotoxic Proteins

Funding details

• 1

  We are grateful to M.T. Almeida and M. Martins who made preliminary observations on the Gp96?NMHCIIA interaction. We are thankful to P. Cossart from Institut Pasteur, Paris, France; O.V. Vieira from CEDOC, Nova Medical School Lisbon, Portugal; and G. Van der Goot from ?cole Polytechnique F?d?rale de Lausanne, Switzerland, for the kind gift of purified LLO, SLO and aerolysin, respectively. We thank C. Leit?o (AFCU), P. Sampaio (ALM) and R. Fernandes (HEMS) from IBMC facilities for technical assistance and J. Bessa and J. Marques for guidance in zebrafish experiments. This work was supported by national funds through FCT?Funda??o para a Ci?ncia e a Tecnologia/MEC?Minist?rio da Educa??o e Ci?ncia and co-funded by Fundo Europeu de Desenvolvimento Regional (FEDER) within the partnership agreement PT2020 related to the research unit number 4293 and through the Operational Competitiveness Programme (COMPETE) under the project ?NORTE-07-0124-FEDER-000002-Host-Pathogen Interactions? co-funded by Programa Operacional Regional do Norte (ON.2?O Novo Norte), under the Quadro de Refer?ncia Estrat?gico Nacional (QREN), through the FEDER and by FCT. It also received support from a Research Grant 2014 by European Society of Clinical Microbiology and Infectious Diseases (ESCMID) (to SS) and from PT2020 research project Infect-ERA/0001/2013 PROANTILIS. Work in the SM Laboratory is supported by a Wellcome Trust Research Career Development Fellowship (WT097411MA) and the Lister Institute of Preventive Medicine. FSM was funded through an EMBO Long-term Post-doctoral Fellowship (EMBO ALTF 864-2012) and a FCT Post-Doctoral Fellowship (SFRH/BPD/94458/2013) through FCT/MEC co-funded by QREN and POPH (Programa Operacional Potencial Humano). CB and JCP received FCT Doctoral Fellowships (SFRH/BD/112217/2015 and SFRH/BD/86871/2012, respectively). SS was supported by FCT Investigator Programme (COMPETE, POPH and FCT).