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Advanced Functional MaterialsVolume 28, Issue 12, 21 March 2018, Article number 1700313

Dendrimers as Powerful Building Blocks in Central Nervous System Disease: Headed for Successful Nanomedicine(Article)

  • ai3S – Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Rua Alfredo Allen 208, Porto, 4200-135, Portugal
  • bINEB – Instituto de Engenharia Biomédica, Universidade do Porto, Rua Alfredo Allen 208, Porto, 4200-135, Portugal
  • cFMUP – Faculdade de Medicina da Universidade do Porto, Alameda Prof. Hernâni Monteiro, Porto, 4200–319, Portugal
  • dICBAS – Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, R. Jorge de Viterbo Ferreira 228, Porto, 4050–343, Portugal
  • eFEUP – Faculdade de Engenharia, Universidade do Porto, Porto, R. Dr. Roberto Frias s/n, Porto, 4200–465, Portugal

Abstract

Dendrimers have emerged as a powerful class of nanomaterials in the nanomedicine field due to their unique structural features: globular, well-defined, highly branched and controllable structure, nanosize-scale, low polydispersity, and the presence of several terminal groups that can be functionalized with different ligands simulating the multivalency present in different biological systems. Although in its infancy, the application of dendrimers as therapeutics or theranostic tools in central nervous system (CNS) disorders is already significant and has opened promising avenues in the treatment of many conditions where the inherent “smartness” of the dendritic structures is being explored to effectively target the CNS. Here we present an overview of the past and future challenges of the use of dendrimers to respond to one of the ultimate challenges in the (nano)medicine field: to attain CNS repair and regeneration. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

Author keywords

blood-brain-barrier (BBB)cell targetingdendrimersneurodegenerative diseasesneurological diseasessurface functionalization

Indexed keywords

Engineering controlled terms:DendrimersFunctional polymersMedical nanotechnologyNeurodegenerative diseasesNeurophysiology
Engineering uncontrolled termsBlood-brain barrierCell targetingCentral nervous systemsControllable structuresDendritic structuresNeurological diseaseStructural featureSurface Functionalization
Engineering main heading:Neurology

Funding details

Funding sponsor Funding number Acronym
Fundação Portugal Telecom
POCI-01-0145-FEDER-016639,SFRH/BPD/109297/2015,NORTE-01-0145-FEDER-000012,PTDC/CTM-NAN/3547/2014
Cosmopolitan Diabetes Foundation
See opportunities
COMPETE 2020
European Regional Development Fund
FIS-2015-01_CCV_20150630-88
NORTE 2020

  • 1

    V Leiro, SD Santos, and CDF Lopes contributed equally to this work. The authors would like to acknowledge the financial support of the Fundo para a Investiga??o em Sa?de (INFARMED, project reference FIS-2015-01_CCV_20150630-88), as well as the FEDER funds through the Programa Operacional Competitividade e Internacionaliza??o ? COMPETE 2020 and the Portuguese funds through FCT ? Funda??o para a Ci?ncia e a Tecnologia in the frame of the project POCI-01-0145-FEDER-016639 (reference PTDC/CTM-NAN/3547/2014). SD Santos is supported by FCT funds (SFRH/BPD/109297/2015). V Leiro is supported by the project NORTE-01-0145-FEDER-000012, financed by Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF).

  • ISSN: 1616301X
  • CODEN: AFMDC
  • Source Type: Journal
  • Original language: English
  • DOI: 10.1002/adfm.201700313
  • Document Type: Article
  • Publisher: Wiley-VCH Verlag

  Paula Pêgo, A.; i3S – Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Rua Alfredo Allen 208, Porto, Portugal;
© Copyright 2018 Elsevier B.V., All rights reserved.

Cited by 6 documents

Zhong, D. , Wu, H. , Wu, Y.
Rational design and facile fabrication of biocompatible triple responsive dendrimeric nanocages for targeted drug delivery
(2019) Nanoscale
Nabi, B. , Rehman, S. , Khan, S.
Ligand conjugation: An emerging platform for enhanced brain drug delivery
(2018) Brain Research Bulletin
Ran, W. , Xue, X.
Theranostical application of nanomedicine for treating central nervous system disorders
(2018) Science China Life Sciences
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