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Progress in Materials ScienceVolume 89, August 2017, Pages 306-344

Functionalized materials for multistage platforms in the oral delivery of biopharmaceuticals(Review)

  • ai3S – Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, 4200-135, Portugal
  • bINEB – Instituto de Engenharia Biomédica, Universidade do Porto, Porto, 4200-135, Portugal
  • cICBAS – Instituto Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, 4150-180, Portugal
  • dDivision of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, FI-00014, Finland
  • eHelsinki Institute of Life Science, HiLIFE, University of Helsinki, Helsinki, FI-00014, Finland
  • fCESPU, Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Gandra, 4585-116, Portugal

Abstract

Recent developments in materials science and specific surface functionalization of materials are providing new tools for the rational design of precisely engineered drug delivery systems. Particular interest has been paid to the exploitation of functionalized materials in the administration of biopharmaceuticals by the oral route, traditionally challenging and frequently compromised when using conventional pharmaceutical approaches. Using such materials for producing particulate systems is a common approach to obtain advanced drug delivery systems capable of providing stable and biocompatible environments and allowing for a targeted delivery of the associated biopharmaceuticals. This work intends to provide a thorough, up-to-date and holistic discussion on specific engineering and surface functionalization strategies of multistage platforms towards the development of novel delivery platforms for oral drug administration, with particular focus on the different materials and their interactions at the biological-material-host interface. This review will also address the safety and toxicity concerns of the resulting drug delivery systems, as well as their regulatory status and pathway towards the market approval of novel biopharmaceutical products based on particulate delivery systems. © 2017 Elsevier Ltd

Author keywords

BiomaterialsBiopharmaceuticalsMultistage platformsOral deliverySurface functionalization

Indexed keywords

Engineering controlled terms:BiocompatibilityBiological materialsBiomaterialsControlled drug deliveryDrug productsInterfaces (materials)
Engineering uncontrolled termsBiopharmaceutical productsBiopharmaceuticalsDrug delivery systemFunctionalized materialsMultistage platformsOral deliveryParticulate delivery systemsSurface Functionalization
Engineering main heading:Targeted drug delivery

Funding details

Funding sponsor Funding number Acronym
POCI-01-0145-FEDER-007274
Academy of Finland252215,281300
Seventh Framework Programme310892,SFRH/BD/87016/2012,SFRH/BPD/92934/2013
European Research Council
4704580
POCI

  • 1

    This work was financed by FEDER ? Fundo Europeu de Desenvolvimento Regional funds through the COMPETE 2020 ? Operacional Programme for Competitiveness and Internationalisation (POCI), Portugal 2020, and by Portuguese funds through FCT ? Funda??o para a Ci?ncia e a Tecnologia/Minist?rio da Ci?ncia, Tecnologia e Inova??o in the framework of the project ?Institute for Research and Innovation in Health Sciences? (POCI-01-0145-FEDER-007274). Dr. H.A. Santos acknowledges financial support from the Academy of Finland (decisions no. 252215 and 281300), the University of Helsinki Research Funds, the Biocentrum Helsinki, Sigrid Jus?liuksen S??ti? (decision no. 4704580) and the European Research Council under the European Union's Seventh Framework Programme (FP/2007?2013, grant no. 310892). Francisca Ara?jo and Jos? das Neves would like to thank FCT for financial support (SFRH/BD/87016/2012 and SFRH/BPD/92934/2013, respectively).

  • ISSN: 00796425
  • CODEN: PRMSA
  • Source Type: Journal
  • Original language: English
  • DOI: 10.1016/j.pmatsci.2017.05.001
  • Document Type: Review
  • Publisher: Elsevier Ltd

  Sarmento, B.; i3S – Instituto de Investigação e Inovação em Saúde da Universidade do Porto, Portugal and INEB – Instituto de Engenharia Biomédica, Universidade do Porto, Rua Alfredo Allen, 208, Porto, Portugal;
© Copyright 2018 Elsevier B.V., All rights reserved.

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