Skip Main Navigation Links Jump to Footer

Scopus Preview

Scientific ReportsVolume 7, Issue 1, 1 December 2017, Article number 4845

Nuclear receptors connect progenitor transcription factors to cell cycle control(Article)(Open Access)

  • aCABD, Andalusian Centre for Developmental Biology, CSIC-UPO-JA, Seville, 41013, Spain
  • bSchool of Medicine, University of Leuven, box 602, Leuven, 3000, Belgium
  • cI3S - Instituto de Investigação e Inovação em Saúde, Universidade Do Porto Portugal, Rua Alfredo Allen, 208, Porto, 4200-135, Portugal
  • dIBMC - Instituto de Biologia Molecular e Celular, Universidade Do Porto Portugal, Rua Alfredo Allen, 208, Porto, 4200-135, Portugal
  • eDepartment of Medical Biology L2-109, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands

Abstract

The specification and growth of organs is controlled simultaneously by networks of transcription factors. While the connection between these transcription factors with fate determinants is increasingly clear, how they establish the link with the cell cycle is far less understood. Here we investigate this link in the developing Drosophila eye, where two transcription factors, the MEIS1 homologue hth and the Zn-finger tsh, synergize to stimulate the proliferation of naïve eye progenitors. Experiments combining transcriptomics, open-chromatin profiling, motif analysis and functional assays indicate that these progenitor transcription factors exert a global regulation of the proliferation program. Rather than directly regulating cell cycle genes, they control proliferation through an intermediary layer of nuclear receptors of the ecdysone/estrogen-signaling pathway. This regulatory subnetwork between hth, tsh and nuclear receptors might be conserved from Drosophila to mammals, as we find a significant co-overexpression of their human homologues in specific cancer types. © 2017 The Author(s).

Indexed keywords

EMTREE drug terms:cell receptorDrosophila proteinhomeodomain proteinhomothorax protein, Drosophilarepressor proteintsh protein, Drosophila
EMTREE medical terms:animalcell cycle checkpointcell proliferationchromatinDrosophilaembryologyeyegene expression profilingmetabolismsignal transduction
MeSH:AnimalsCell Cycle CheckpointsCell ProliferationChromatinDrosophilaDrosophila ProteinsEyeGene Expression ProfilingHomeodomain ProteinsReceptors, Cytoplasmic and NuclearRepressor ProteinsSignal Transduction

Chemicals and CAS Registry Numbers:

Chromatin; Drosophila Proteins; Homeodomain Proteins; homothorax protein, Drosophila; Receptors, Cytoplasmic and Nuclear; Repressor Proteins; tsh protein, Drosophila

Funding details

Funding sponsor Funding number Acronym
OT/13/103
Fonds Wetenschappelijk OnderzoekG. 0791.14,G. 0640.13
Fonds Wetenschappelijk Onderzoek
Ministerio de Economía y Competitividad

  • 1

    Grants BFU2012-34324 and BFU2015-66040 (MINECO, Spain) to F.C. Grants from Research Foundation Flanders (FWO, grants G. 0640.13 and G. 0791.14), University of Leuven (OT/13/103) to SA. MNS was funded by a PhD fellowship from FWO.

  • ISSN: 20452322
  • Source Type: Journal
  • Original language: English
  • DOI: 10.1038/s41598-017-04936-7
  • PubMed ID: 28687780
  • Document Type: Article
  • Publisher: Nature Publishing Group

  Aerts, S.; School of Medicine, University of Leuven, box 602, Leuven, Belgium;
© Copyright 2017 Elsevier B.V., All rights reserved.

Cited by 3 documents

Sitaram, P. , Lu, S. , Harsh, S.
Next-generation sequencing reveals increased anti-oxidant response and ecdysone signaling in STAT supercompetitors in Drosophila
(2019) G3: Genes, Genomes, Genetics
Sánchez-Aragón, M. , Cantisán-Gómez, J. , Luque, C.M.
A toggle-switch and a feed-forward loop engage in the control of the Drosophila retinal determination gene network
(2019) Frontiers in Ecology and Evolution
Song, S. , Andrejeva, D. , Freitas, F.C.P.
DTcf/Pangolin suppresses growth and tumor formation in Drosophila
(2019) Proceedings of the National Academy of Sciences of the United States of America
View details of all 3 citations
Inform me when this document is cited in Scopus:
Set citation alert Set citation feed
{"topic":{"name":"Eye; Drosophila; Transcription factors","id":17476,"uri":"Topic/17476","prominencePercentile":85.811356,"prominencePercentileString":"85.811","overallScholarlyOutput":0},"dig":"c6395de6738f30ce042701b58e4edb924bdb7a26b8922759d7bde8d440027e6f"}

SciVal Topic Prominence

Topic:
Prominence percentile: