

Oncocytomas are distinct tumors characterized by an abnormal accumulation of defective and (most probably) dysfunctional mitochondria in cell cytoplasm of such tumors. This particular phenotype has been studied for the last decades and the clarification of the etiopathogenic causes are still needed. Several mechanisms involved in the formation and maintenance of oncocytomas are accepted as reasonable causes, but the relevance and contribution of each one for oncocytic transformation may depend on different cancer etiopathogenic contexts. In this review, we describe the current knowledge of the etiopathogenic events that may lead to oncocytic transformation and discuss their contribution for tumor progression and mitochondrial accumulation. © 2017 Elsevier Ltd
| EMTREE medical terms: | cancer susceptibilitycarcinogenesiscell deathcell proliferationdisorders of mitochondrial functionsgenegene mutationgenetic predispositiongenomicshereditary tumor syndromehumankidney tumormitochondrial biogenesismitophagymtDNA genenonhumanoncocytomaReviewthyroid tumortumor growthanimalautophagycell transformationgeneticsmetabolismmitochondriononcocytoma |
|---|---|
| MeSH: | Adenoma, OxyphilicAnimalsAutophagyCell Transformation, NeoplasticHumansMitochondriaMitochondrial Degradation |
| Funding sponsor | Funding number | Acronym |
|---|---|---|
| SFRH/BD/111321/2015,UID/BIM/04293/2013 | ||
| POCI,NORTE-01-0145-FEDER-000029,POCI-01-0145-FEDER-007274 |
This work was supported by Portuguese funds through FCT ? Funda??o para a Ci?ncia e a Tecnologia ? in the framework of project UID/BIM/04293/2013 and through a PhD grant to RB SFRH/BD/111321/2015. It was also financed by FEDER ? Fundo Europeu de Desenvolvimento Regional funds through the COMPETE 2020 ? Operational Program for Competitiveness and Internationalization (POCI), Portugal 2020, and by Portuguese funds through FCT ? Funda??o para a Ci?ncia e Tecnologia/Minist?rio da Ci?ncia, Tecnologia e Inova??o in the framework of the projects ?Institute for Research and Innovation in Health Sciences? (POCI-01-0145-FEDER-007274). Further funding was obtained from the project ?Advancing cancer research: from basic knowledgment to application? NORTE-01-0145-FEDER-000029: ?Projetos Estruturados de I&D&I?, funded by Norte 2020 ? Programa Operacional Regional do Norte.
Máximo, V.; IPATIMUP, Rua Dr. Roberto Frias S/N, Porto, Portugal;
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