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Seminars in Cancer BiologyVolume 47, December 2017, Pages 82-94

Etiopathogenesis of oncocytomas(Review)

  • aCancer Signalling and Metabolism Research Group, Instituto de Investigação e Inovação em Saúde – i3S (Institute for Research and Innovation in Health), University of Porto, Porto, Portugal
  • bCancer Signalling and Metabolism Research Group, Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal
  • cFaculdade de Medicina da Universidade do Porto – FMUP (Medical Faculty of University of Porto), Porto, Portugal
  • dDepartment of Pathology, Faculdade de Medicina da Universidade do Porto – FMUP (Medical Faculty of University of Porto), Porto, Portugal
  • eDepartment of Pathology, Centro Hospitalar São João, Porto, Portugal

Abstract

Oncocytomas are distinct tumors characterized by an abnormal accumulation of defective and (most probably) dysfunctional mitochondria in cell cytoplasm of such tumors. This particular phenotype has been studied for the last decades and the clarification of the etiopathogenic causes are still needed. Several mechanisms involved in the formation and maintenance of oncocytomas are accepted as reasonable causes, but the relevance and contribution of each one for oncocytic transformation may depend on different cancer etiopathogenic contexts. In this review, we describe the current knowledge of the etiopathogenic events that may lead to oncocytic transformation and discuss their contribution for tumor progression and mitochondrial accumulation. © 2017 Elsevier Ltd

Author keywords

AutophagyMitochondria-rich tumorsMitophagymtDNAOncocytomas

Indexed keywords

EMTREE medical terms:cancer susceptibilitycarcinogenesiscell deathcell proliferationdisorders of mitochondrial functionsgenegene mutationgenetic predispositiongenomicshereditary tumor syndromehumankidney tumormitochondrial biogenesismitophagymtDNA genenonhumanoncocytomaReviewthyroid tumortumor growthanimalautophagycell transformationgeneticsmetabolismmitochondriononcocytoma
MeSH:Adenoma, OxyphilicAnimalsAutophagyCell Transformation, NeoplasticHumansMitochondriaMitochondrial Degradation

Funding details

Funding sponsor Funding number Acronym
SFRH/BD/111321/2015,UID/BIM/04293/2013
POCI,NORTE-01-0145-FEDER-000029,POCI-01-0145-FEDER-007274
  • 1

    This work was supported by Portuguese funds through FCT ? Funda??o para a Ci?ncia e a Tecnologia ? in the framework of project UID/BIM/04293/2013 and through a PhD grant to RB SFRH/BD/111321/2015. It was also financed by FEDER ? Fundo Europeu de Desenvolvimento Regional funds through the COMPETE 2020 ? Operational Program for Competitiveness and Internationalization (POCI), Portugal 2020, and by Portuguese funds through FCT ? Funda??o para a Ci?ncia e Tecnologia/Minist?rio da Ci?ncia, Tecnologia e Inova??o in the framework of the projects ?Institute for Research and Innovation in Health Sciences? (POCI-01-0145-FEDER-007274). Further funding was obtained from the project ?Advancing cancer research: from basic knowledgment to application? NORTE-01-0145-FEDER-000029: ?Projetos Estruturados de I&D&I?, funded by Norte 2020 ? Programa Operacional Regional do Norte.

  • ISSN: 1044579X
  • CODEN: SECBE
  • Source Type: Journal
  • Original language: English
  • DOI: 10.1016/j.semcancer.2017.06.014
  • PubMed ID: 28687249
  • Document Type: Review
  • Publisher: Academic Press

  Máximo, V.; IPATIMUP, Rua Dr. Roberto Frias S/N, Porto, Portugal;
© Copyright 2018 Elsevier B.V., All rights reserved.

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