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Trends in BiotechnologyVolume 36, Issue 4, April 2018, Pages 343-347

Gravity, Tissue Engineering, and the Missing Link(Short Survey)

  • a3B's Research Group – Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Avepark – Parque de Ciência e Tecnologia, Zona Industrial da Gandra, Barco, Guimarães, 4805-017, Portugal
  • bICVS/3B's – PT Government Associate Laboratory, Guimarães, Portugal
  • ci3S − Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Rua Alfredo Allen, 208, Porto, 4200-135, Portugal
  • dINEB – Instituto de Engenharia Biomédica, Universidade do Porto, Porto, Portugal
  • eFaculdade de Engenharia, Universidade do Porto, Rua Dr. Roberto Frias, Porto, 4200-465, Portugal
  • fICBAS – Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal
  • gThe Discoveries Centre for Regenerative and Precision Medicine, Headquarters at University of Minho, Avepark, Barco, Guimarães, 4805-017, Portugal

Abstract

The influence of microgravity and hypergravity on living systems has attracted significant attention, but the use of these tools in tissue engineering (TE) remains relatively unexplored. This Forum article highlights an emerging field of research to uncover new potential applications at the interface between altered gravity and TE. © 2017 Elsevier Ltd

Author keywords

cell/tissue biologyhypergravityin vitro 3D culturemicrogravityregenerative medicinetissue engineering

Indexed keywords

Engineering controlled terms:Cell engineeringMicrogravityMicrogravity processingRegenerative MedicineTissue
Engineering uncontrolled terms3-d culturesHypergravityLiving systems
Engineering main heading:Tissue engineering
EMTREE drug terms:biomaterial
EMTREE medical terms:adult stem cellcell differentiationcell fatecell functioncell proliferationcell stimulationembryonic stem cellgravityhumanmesenchymal stem cellmicrogravitymicrotechnologymyoblastnerve cellnonhumanpriority journalregenerative medicineShort Surveyspace flighttissue engineeringumbilical vein endothelial cellanimalcell culture techniquemousePC12 cell lineratweightlessness
MeSH:AnimalsCell Culture TechniquesEmbryonic Stem CellsHuman Umbilical Vein Endothelial CellsHumansHypergravityMesenchymal Stem CellsMicePC12 CellsRatsRegenerative MedicineTissue EngineeringWeightlessness

Funding details

Funding sponsor Funding number Acronym
Fundação para a Ciência e a Tecnologia
See opportunities
Fuel Cell Technologies ProgramSFRH/BD/96593/2013FCT

  • 1

    The authors acknowledge financial support from the Fundação para a Ciência e a Tecnologia (FCT) for PhD scholarship SFRH/BD/96593/2013 (R.C-A.) and for Career Consolidation Grant IF/00593/2015 (M.E.G.).

  • ISSN: 01677799
  • CODEN: TRBID
  • Source Type: Journal
  • Original language: English
  • DOI: 10.1016/j.tibtech.2017.10.017
  • PubMed ID: 29153346
  • Document Type: Short Survey
  • Publisher: Elsevier Ltd

  Gomes, M.E.; The Discoveries Centre for Regenerative and Precision Medicine, Headquarters at University of Minho, Avepark, Barco, Guimarães, Portugal;
© Copyright 2018 Elsevier B.V., All rights reserved.

Cited by 1 document

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Continuous exposure to simulated hypergravity-induced changes in proliferation, morphology, and gene expression of human tendon cells
(2018) Stem Cells and Development
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