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Nature GeneticsVolume 50, Issue 2, 1 February 2018, Pages 199-205

Reconstructing an African haploid genome from the 18th century(Article)

  • Jagadeesan, A.,
  • Gunnarsdóttir, E.D.,
  • Ebenesersdóttir, S.S.,
  • Gumundsdóttir, V.B.,
  • Thordardottir, E.L.,
  • Einarsdóttir, M.S.,
  • Jónsson, H.,
  • Dugoujon, J.-M.,
  • Fortes-Lima, C.,
  • Migot-Nabias, F.,
  • Massougbodji, A.,
  • Bellis, G.,
  • Pereira, L.,
  • Másson, G.,
  • Kong, A.,
  • Stefánsson, K.,
  • Helgason, A.
  • View Correspondence (jump link)
  • aDeCODE Genetics/Amgen, Reykjavik, Iceland
  • bDepartment of Anthropology, University of Iceland, Reykjavik, Iceland
  • cLaboratoire d'Eco-Anthropologie et Ethnobiologie, Equipe d'Anthropologie Evolutive, UMR 7206, Centre National de la Recherche Scientifique (CNRS), Université Diderot Paris 7, Paris, France
  • dInstitut de Recherche pour le Développement, UMR D216 MERIT (Mère et Enfant Face Aux Infections Tropicales), Paris, France
  • eCOMUE Sorbonne Paris Cité, Faculté de Pharmacie, Université Paris Descartes, Paris, France
  • fCentre d'Etude et de Recherche sur le Paludisme Associé À la Grossesse et l'Enfance, Cotonou, Benin
  • gLaboratoire de Parasitologie, Faculté des Sciences de la Santé, Université d'Abomey-Calavi, Cotonou, Benin
  • hInstitut National d'Etudes Démographiques (INED), Paris, France
  • iInstituto de Investigação e Inovação em Saúde (i3S), Universidade Do Porto, Porto, Portugal
  • jInstituto de Patologia e Imunologia Molecular da Universidade Do Porto (IPATIMUP), Porto, Portugal
  • kFaculdade de Medicina da Universidade Do Porto, Porto, Portugal
  • lFaculty of Medicine, University of Iceland, Reykjavik, Iceland

Abstract

A genome is a mosaic of chromosome fragments from ancestors who existed some arbitrary number of generations earlier. Here, we reconstruct the genome of Hans Jonatan (HJ), born in the Caribbean in 1784 to an enslaved African mother and European father. HJ migrated to Iceland in 1802, married and had two children. We genotyped 182 of his 788 descendants using single-nucleotide polymorphism (SNP) chips and whole-genome sequenced (WGS) 20 of them. Using these data, we reconstructed 38% of HJ's maternal genome and inferred that his mother was from the region spanned by Benin, Nigeria and Cameroon. © 2018 The Author(s).

Indexed keywords

EMTREE medical terms:AfricanArticleCaribbeanchromosome 1chromosome 3chromosome analysisEuropeangene flowgene frequencygene poolgenealogygenotypehaplogrouphaploidyhaplotype maphumanhuman genomeIcelandIcelanderpriority journalsingle nucleotide polymorphismwhole genome sequencingX chromosomeY chromosomeBlack personCaribbean Islandscase reportDNA sequencefamily sizegeneticsgenome-wide association studyhistorymalemigrationpedigreeprocedures
MeSH:African Continental Ancestry GroupEnslaved PersonsFamily CharacteristicsGenome, HumanGenome-Wide Association StudyHaploidyHistory, 18th CenturyHumansIcelandMalePedigreePolymorphism, Single NucleotideSequence Analysis, DNATransients and MigrantsWest Indies

Funding details

Funding sponsor Funding number Acronym
163428-051
290344

  • 1

    A.J., H.J. and C.F.-L. were funded by the EUROTAST Marie Curie Framework Programme 7 Initial Training Network 290344). We thank all the members of EUROTAST network for their helpful comments and suggestions. S.S.E. and V.B.G. received grants from The Research Fund of University of Iceland for doctoral studies. M.S.E. received a grant from the Icelandic Research Fund (163428-051).We thank E. Soumonni, a historian whose advice guided the recruitment of Beninese individuals, and J.-P. Chippaux (CERPAGE, Cotonou, Benin) for his help with local authorities.

  • ISSN: 10614036
  • CODEN: NGENE
  • Source Type: Journal
  • Original language: English
  • DOI: 10.1038/s41588-017-0031-6
  • PubMed ID: 29335549
  • Document Type: Article
  • Publisher: Nature Publishing Group

  Stefánsson, K.; DeCODE Genetics/Amgen, Reykjavik, Iceland;
© Copyright 2019 Elsevier B.V., All rights reserved.

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