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Materials Science and Engineering CVolume 93, 1 December 2018, Pages 816-827

Biomechanical performance of hybrid electrospun structures for skin regeneration(Article)

  • ai3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal
  • bCentre for Rapid and Sustainable Product Development (CDRsp), Polytechnic Institute of Leiria, Leiria, Portugal
  • cINEB - Instituto de Engenharia Biomédica, Universidade do Porto, Porto, Portugal
  • dICBAS - Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal
  • eCBQF - Center for Biotechnology and Fine Chemistry, School of Biotechnology, Portuguese Catholic University, Porto, Portugal
  • fFaculdade de Engenharia da Universidade do Porto (FEUP), Porto, Portugal
  • gSchool of Mechanical, Aerospace and Civil Engineering & Manchester Institute of Biotechnology, University of Manchester, United Kingdom

Abstract

Wound dressings made by electrospun nanofibers have been demonstrating great potential to regenerate skin tissue as compared to the conventional membrane products available in the market. Until today most of the developed dressings have only demonstrated the capability to regenerate the dermis or epidermis. In this study we propose new hybrid electrospun meshes combining polycaprolactone and gelatin. Several approaches, multilayer, coating and blend were stablished to investigate the most appropriate hybrid structure with potential to promote skin regeneration in its full thickness. The structures were evaluated in terms of physico-chemical properties (porosity, water vapor permeability, contact angle and swelling degree) and according to its mechanical and biological performance. Multilayer and blend structures demonstrated to fit most of native skin requirements. However, looking to all the performed characterization we considered multilayer as the most promising hybrid structures, due its high porosity which contributed to an ideal water vapor permeability rate and good mechanical and biological properties. Based on this multilayer structure is a promisor wound dressing. © 2018 Elsevier B.V.

Author keywords

ECMElectrospun meshesHybrid structuresSkin regenerationWound dressings

Indexed keywords

Engineering controlled terms:BlendingContact angleMilitary electronic countermeasuresMultilayersPorosityWater vapor
Engineering uncontrolled termsBiomechanical performanceElectrospun nanofibersElectrospunsHybrid structurePhysicochemical propertySkin regenerationWater vapor permeabilityWound dressings
Engineering main heading:Mechanical permeability
EMTREE drug terms:biocompatible coated materialgelatinnanofiberpolycaprolactonepolyester
EMTREE medical terms:bandagebiomechanicscell culture techniquecell proliferationcell survivalchemistrycytologyfibroblasthumanmalemetabolismnewbornphysiologyproceduresregenerationskintissue engineeringtissue scaffoldwound healing
MeSH:BandagesBiomechanical PhenomenaCell Culture TechniquesCell ProliferationCell SurvivalCoated Materials, BiocompatibleFibroblastsGelatinHumansInfant, NewbornMaleNanofibersPolyestersRegenerationSkinTissue EngineeringTissue ScaffoldsWound Healing

Chemicals and CAS Registry Numbers:

gelatin, 9000-70-8; polycaprolactone, 24980-41-4, 25248-42-4;

Coated Materials, Biocompatible; Gelatin; polycaprolactone; Polyesters

Funding details

Funding sponsor Funding number Acronym
Fundação para a Ciência e a Tecnologia
See opportunities
Programa Operacional Temático Factores de Competitividade
Fundação para a Ciência e a Tecnologia
See opportunities		SFRH/BPD/90047/2012,SFRH/BD/91104/2012,IF/00411/2013
European Regional Development Fund
Programa Operacional Temático Factores de CompetitividadeCOMPETE

  • 1

    This study was supported by the Projects PTDC/BBB-ECT/2145/2014 and UID/Multi/04044/2013 , financed by European Regional Development Fund (ERDF) through the Portuguese national programs Programa Operacional Factores de Competitividade (COMPETE), Portugal2020 and Norte2020, and by Portuguese funds through Fundação para a Ciência e a Tecnologia (FCT). This work is also supported by the research grants SFRH/BD/91104/2012 awarded to Juliana Dias and SFRH/BPD/90047/2012 awarded to Aureliana Sousa by FCT , and by the Investigator FCT program IF/00411/2013 , awarded to Ana L. Oliveira. The authors thanks to CEMUP, University of Porto for the SEM images.

  • ISSN: 09284931
  • Source Type: Journal
  • Original language: English
  • DOI: 10.1016/j.msec.2018.08.050
  • PubMed ID: 30274117
  • Document Type: Article
  • Publisher: Elsevier Ltd

  Dias, J.R.; Biomaterials for Multistage Drug & Cell Delivery Group, Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Rua Alfredo Allen, 208, Porto, Portugal;
© Copyright 2018 Elsevier B.V., All rights reserved.

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