Skip Main Navigation Links Jump to Footer

Scopus Preview

Critical Reviews in MicrobiologyVolume 44, Issue 6, 2 November 2018, Pages 685-700

Scavenger Receptors: Promiscuous Players during Microbial Pathogenesis(Review)

  • aInstituto de Investigação e Inovação em Saúde (i3S), Group of Molecular Microbiology, Universidade do Porto, Porto, Portugal
  • bInstituto de Biologia Molecular e Celular (IBMC), Group of Molecular Microbiology, Universidade do Porto, Porto, Portugal

Abstract

Innate immunity is the most broadly effective host defense, being essential to clear the majority of microbial infections. Scavenger Receptors comprise a family of sensors expressed in a multitude of host cells, whose dual role during microbial pathogenesis gained importance over recent years. SRs regulate the recruitment of immune cells and control both host inflammatory response and bacterial load. In turn, pathogens have evolved different strategies to overcome immune response, avoid recognition by SRs and exploit them to favor infection. Here, we discuss the most relevant findings regarding the interplay between SRs and pathogens, discussing how these multifunctional proteins recognize a panoply of ligands and act as bacterial phagocytic receptors. © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group.

Author keywords

Innate immune responsemicrobial pathogenesispathogensscavenger receptors

Indexed keywords

EMTREE drug terms:CD206 receptorCD36 antigenCXCL16 chemokinedectin 1LOX 1 receptorMARCO receptorscavenger receptorscavenger receptor Ascavenger receptor BSREC receptorstabilin 1unclassified drugscavenger receptor
EMTREE medical terms:humanmicrobiologynonhumanpathogenesispriority journalReviewanimalbacterial infectionbacterial phenomena and functionsbacteriumgeneticsimmunologyinnate immunitymicrobiologypathogenicity
MeSH:AnimalsBacteriaBacterial InfectionsBacterial Physiological PhenomenaHumansImmunity, InnateReceptors, Scavenger

Chemicals and CAS Registry Numbers:

Receptors, Scavenger

Funding details

Funding sponsor Funding number Acronym
Programa Operacional Temático Factores de Competitividade
Fundação para a Ciência e a Tecnologia
See opportunities
European Regional Development Fund
NORTE 2020
Federación Española de Enfermedades Raras

  • 1

    This work received funding from Norte-01–0145-FEDER-000012 – Structured program on bioengineered therapies for infectious diseases and tissue regeneration, supported by Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL Partnership Agreement, through the European Regional Development Fund (FEDER). R.P received an FCT Doctoral Fellowship [SFRH/BD/89542/2012] through FCT/MEC co-funded by QREN and POPH (Programa Operacional Potencial Humano). SS was supported by FCT Investigator program (COMPETE, POPH, and FCT).

  • ISSN: 1040841X
  • CODEN: CRVMA
  • Source Type: Journal
  • Original language: English
  • DOI: 10.1080/1040841X.2018.1493716
  • PubMed ID: 30318962
  • Document Type: Review
  • Publisher: Taylor and Francis Ltd

  Cabanes, D.; Instituto de Investigação e Inovação em Saúde (i3S), Group of Molecular Microbiology, Universidade do Porto, Rua Alfredo Allen, 208, Porto, Portugal;
© Copyright 2019 Elsevier B.V., All rights reserved.

Cited by 0 documents

Inform me when this document is cited in Scopus:
Set citation alert Set citation feed
{"topic":{"name":"Receptors, Scavenger; Macrophages; Scavenger Receptors, Class A","id":17407,"uri":"Topic/17407","prominencePercentile":79.68667,"prominencePercentileString":"79.687","overallScholarlyOutput":0},"dig":"d2436443ada6083e07ec0714cbc522e43f74e0bdca4af2ae3af83ab2ba93ab05"}

SciVal Topic Prominence

Topic:
Prominence percentile: