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Development (Cambridge)Volume 146, Issue 8, 15 April 2019, Article number dev176933

Dynamic Hh signalling can generate temporal information during tissue patterning(Article)(Open Access)

  • aCABD (CSIC-Universidad Pablo de Olavide-Junta de Andalucía), GEM-DMC2 Unit, Campus UPO, Seville, 41013, Spain
  • bInstituto de Biologia Molecular e Celular/i3S, Universidade do Porto, Porto, 4200-135, Portugal
  • cCentro de Biología Molecular Severo Ochoa (CSIC-UAM), Campus de Cantoblanco, Madrid, 28049, Spain

Abstract

The differentiation of tissues and organs requires that cells exchange information in space and time. Spatial information is often conveyed by morphogens: molecules that disperse across receiving cells to generate signalling gradients. Cells translate such concentration gradients into space-dependent patterns of gene expression and cellular behaviour.But could morphogen gradients also convey developmental time? Here, by investigating the developmental role of Hh on a component of the Drosophila visual system, the ocellar retina, we have discovered that ocellar cells use the non-linear gradient of Hh as a temporal cue, collectively performing the biological equivalent of a mathematical logarithmic transformation. In this way, a morphogen diffusing from a non-moving sourceis decodedas awaveof differentiating photoreceptors that travels at constant speed throughout the retinal epithelium. © 2019. Published by The Company of Biologists Ltd.

Author keywords

DrosophilaHedgehogPatterningSystems modellingVisual system

Indexed keywords

EMTREE drug terms:ELAV proteinmorphogenpeptides and proteinsprotein Patchedsenseless proteinsonic hedgehog proteinunclassified drug
EMTREE medical terms:adultanimal structuresanimal tissueArticleassociationaxial patterningcell differentiationcontrolled studyDrosophilahedgehog signalinginformationmathematical modelmorphogenesisnonhumanocellar cellocellar retinaphotoreceptorphotoreceptor cellpriority journalprotein expressionprotein protein interactionretinaretina cellretinal pigment epitheliumspatiotemporal analysistemporal patterningvisual feedbackvisual system

Funding details

Funding sponsor Funding number Acronym
Ministerio de Ciencia e Innovación
  • 1

    Research was funded through grants BFU2015-66040-P and MDM-2016-0687 (to F.C.) and BFU2014-53299-P (to D.G.M.) from the Ministerio de Ciencia, Innovación y Universidades (Spain).

  • ISSN: 09501991
  • CODEN: DEVPE
  • Source Type: Journal
  • Original language: English
  • DOI: 10.1242/dev.176933
  • PubMed ID: 30918051
  • Document Type: Article
  • Publisher: Company of Biologists Ltd

  Casares, F.; CABD (CSIC-Universidad Pablo de Olavide-Junta de Andalucía), GEM-DMC2 Unit, Campus UPO, Seville, Spain;
© Copyright 2019 Elsevier B.V., All rights reserved.

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