

The differentiation of tissues and organs requires that cells exchange information in space and time. Spatial information is often conveyed by morphogens: molecules that disperse across receiving cells to generate signalling gradients. Cells translate such concentration gradients into space-dependent patterns of gene expression and cellular behaviour.But could morphogen gradients also convey developmental time? Here, by investigating the developmental role of Hh on a component of the Drosophila visual system, the ocellar retina, we have discovered that ocellar cells use the non-linear gradient of Hh as a temporal cue, collectively performing the biological equivalent of a mathematical logarithmic transformation. In this way, a morphogen diffusing from a non-moving sourceis decodedas awaveof differentiating photoreceptors that travels at constant speed throughout the retinal epithelium. © 2019. Published by The Company of Biologists Ltd.
| EMTREE drug terms: | ELAV proteinmorphogenpeptides and proteinsprotein Patchedsenseless proteinsonic hedgehog proteinunclassified drug |
|---|---|
| EMTREE medical terms: | adultanimal structuresanimal tissueArticleassociationaxial patterningcell differentiationcontrolled studyDrosophilahedgehog signalinginformationmathematical modelmorphogenesisnonhumanocellar cellocellar retinaphotoreceptorphotoreceptor cellpriority journalprotein expressionprotein protein interactionretinaretina cellretinal pigment epitheliumspatiotemporal analysistemporal patterningvisual feedbackvisual system |
| Funding sponsor | Funding number | Acronym |
|---|---|---|
| Ministerio de Ciencia e Innovación |
Research was funded through grants BFU2015-66040-P and MDM-2016-0687 (to F.C.) and BFU2014-53299-P (to D.G.M.) from the Ministerio de Ciencia, Innovación y Universidades (Spain).
Casares, F.; CABD (CSIC-Universidad Pablo de Olavide-Junta de Andalucía), GEM-DMC2 Unit, Campus UPO, Seville, Spain;
© Copyright 2019 Elsevier B.V., All rights reserved.