Transformation of steroidal 5α,8α-peroxides to the 14-membered ring containing 5,10;8,9-diseco-steroid derivatives(Article)
- aDepartment of Chemistry, Faculty of Science, University of Belgrade, Studentski trg 16, P.O.Box 550, YU-11001 Belgrade
- bInstitute of Chemistry, Technology and Metallurgy, Belgrade
Abstract
Thermal decomposition of steroidal 5α,8α-peroxides (such as 1) resulted in bisfragmentation of the C(5)-C(10) and C(8)-C(9) bonds, and elimination of acetic acid, to produce a new type of bicyclic compounds, namely 5,10;8,9-diseco-steroid derivatives (such as 2). some chemical transformations of product 2 are described. © 1985.
Indexed keywords
| EMTREE medical terms: | 5,10:8,9 disecosteroiddrug analysisdrug identificationdrug synthesismass spectrometrynonhumannuclear magnetic resonancepreliminary communicationpriority journaltheoretical study |
|---|---|
Funding details
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1
Acknowledgemen te. The authors are grateful to the Serbian Academy of Sciences and Arts and to the Serbian Research Fund for financial support. They also wish to express their thanks to Mrs. G. Rihs for the X-ray analysis of compound 8, to Dr. H. Fuhrer for measurement of and comments on NMR spectra, and to Dr. J. Kalvoda (all from Ciba-Geigy Ltd., Basle, Switzerland) for helpful discussions. A full and detailed report, with these authors, will soon be published elsewhere.
- ISSN: 00404039
- CODEN: TELEA
- Source Type: Journal
- Original language: English
- DOI: 10.1016/S0040-4039(01)80825-X
- Document Type: Article
Lorenc, Lj.; Department of Chemistry, Faculty of Science, University of Belgrade, Studentski trg 16, P.O.Box 550,
© Copyright 2014 Elsevier B.V., All rights reserved.
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