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Bioorganic and Medicinal Chemistry LettersVolume 1, Issue 8, 1991, Pages 403-406

Synthesis and evaluation of several cathechol bioisosteres as potential dopamine receptor ligands(Article)

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  • aInstitute for Chemistry, Tehcnology and Metallurgy, 11060 Belgrade, Yugoslavia
  • bFaculty of Chemistry, University of Belgrade, 11060 Belgrade
  • cInstitute for Biological Reseach, 11060 Belgrade

Abstract

Derivatives of benzimidazole (I), benzimidazolone (II), benzimidazolethione (III), 2,3-dihydroxyquinoxaline (IV) and the noncyclic acetamide (V) and t rifluoroacetamide (VI) of the corresponding 1,2-pheny-lenediamiane were synthesized and tested for DA-ergic activity. III and IV had a moderate affini ty for the D2 receptors of the bovine caudate nucleus. © 1991.

Indexed keywords

EMTREE drug terms:5 (2 dipropylaminoethyl) 1,3 dihydro 2h benzimidazole 2 thione5 (2 dipropylaminoethyl) 2,3 quinoxalinedioneacetamide derivativeamidebenzimidazole derivativedopaminedopamine 1 receptordopamine 2 receptorspiperoneunclassified drug
EMTREE medical terms:articlebraincattledrug receptor bindingdrug synthesisnonhumanstructure activity relation
Species Index:Bos taurusBovinae
  • ISSN: 0960894X
  • CODEN: BMCLE
  • Source Type: Journal
  • Original language: English
  • DOI: 10.1016/S0960-894X(00)80265-6
  • Document Type: Article

  Kotić, S.;
© Copyright 2018 Elsevier B.V., All rights reserved.

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