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Archives of Physiology and BiochemistryVolume 100, Issue 1, 1992, Pages 101-103

Evidence that endothelium-dependent relaxation to histamine in the rat common carotid artery is mediated by EDRF(Article)

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  • aDepartment of Pharmacology, Faculty of Medicine, Belgrade, Yugoslavia, Serbia
  • bDepartment of Pharmacology, Faculty of Pharmacy, Belgrade, Yugoslavia, Serbia

Abstract

The mechanism of histamine-induced relaxation in the isolated rat common carotid artery was analysed. Histamine (3 × 10-7 -10-4 mol/1) caused a concentration-dependent relaxation of the artery. In-domethacin, a cyclo-oxygenase inhibitor, and diethylcarbamazine, a lipoxygenase inhibitor, did not affect the relaxant response of the artery to histamine. After removal of the vascular endothelium the histamine-induced relaxation was strongly reduced. Moreover, hemoglobin and methylene blue, inhibitors of endothelium-derived relaxing factor (EDRF), prevented or reversed the relaxant effect of histamine. These findings confirm that the histamine-induced relaxation is to a greater extent endothelium dependent. It is concluded that the endothelium-dependent component in the relaxant response of the rat common carotid artery to histamine results from the release of EDRF. © 1992 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

Indexed keywords

EMTREE drug terms:histaminenitric oxide
EMTREE medical terms:animalarticlecarotid arterydrug effectfemalemalephysiologyratvascular endotheliumvasodilatation
MeSH:AnimalCarotid ArteriesEndothelium, VascularFemaleHistamineMaleNitric OxideRatsSupport, Non-U.S. Gov'tVasodilation

Chemicals and CAS Registry Numbers:

histamine, 51-45-6, 56-92-8, 93443-21-1; nitric oxide, 10102-43-9;

Histamine, 51-45-6; Nitric Oxide, 10102-43-9

Funding details

Funding sponsor Funding number Acronym
231

  • 1

    Acknowledgment - This work was supported by the Scientific Fund of Serbia (Grant No. 231).

  • ISSN: 13813455
  • CODEN: APBIF
  • Source Type: Journal
  • Original language: English
  • DOI: 10.3109/13813459209035267
  • PubMed ID: 1380324
  • Document Type: Article
  • Publisher: Informa Healthcare

  Krstić, M.K.; Department of Pharmacology, Faculty of Medicine, Serbia
© Copyright 2014 Elsevier B.V., All rights reserved.

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