Foot‐and‐Mouth Disease Virus C3 Resende Subtype Analysed by Means of Competition RIA Using Neutralizing Monoclonal Antibodies(Article)
- Department of Infectious diseases of animals and bees, Veterinary Faculty, University of Belgrade
Abstract
Foot‐and‐mouth disease virus (FMDV) was analysed using 30 monoclonal antibodies (MAbs) obtained from Balb/c mice immunized with FMDV C3 Resende (C3R) subtype 7 and 14 days before fusion No. 15 and 16 respectively. Fourteen MAbs were neutralizing and by means of competition radioimmuno assay it was possible to classify them into four groups. The first group consisted of MAbs specific for three sequentional and three conformational epitopes. The second group consisted of MAbs specific for two conformational and for one sequentional epitope. The third and the fourth groups consisted only of one MAb each, being specific for conformationally and one sequentionally dependent epitope, respectively. © 1992 Blackwell Verlag GmbH
Indexed keywords
| EMTREE drug terms: | epitopemonoclonal antibodyvirus antibodyvirus antigen |
|---|---|
| EMTREE medical terms: | animalAphthovirusarticlebinding competitionimmunologyradioimmunoassay |
| MeSH: | AnimalAntibodies, MonoclonalAntibodies, ViralAntigens, ViralAphthovirusBinding, CompetitiveEpitopesRadioimmunoassay |
Chemicals and CAS Registry Numbers:
Antibodies, Monoclonal; Antibodies, Viral; Antigens, Viral; Epitopes
- ISSN: 09311793
- Source Type: Journal
- Original language: English
- DOI: 10.1111/j.1439-0450.1992.tb01158.x
- PubMed ID: 1379398
- Document Type: Article
Valcic, M.A.; Department of Infectious diseases of animals and bees, Veterinary Faculty, University of Belgrade,
© Copyright 2016 Elsevier B.V., All rights reserved.