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FarmacoVolume 47, Issue 3, 1992, Pages 393-396

Spectrophotometric determination of diltiazem in dosage forms(Article)

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  • Pharmaceutical Chemistry Department, Faculty of Pharmacy, Dr. Subotica 8, 11000 Belgrade, Yugoslavia

Abstract

A simple and reproducible method for determination of diltiazem in bulk and in dosage forms is presented. The method is based on formation of hydroxamic acid, which reacts with iron (III), forming a complex with a maximum absorption at 525nm. Assay procedure for diltiazem dosage form requires thin-layer chromatographic separation prior to colorimetric analysis.

Indexed keywords

EMTREE drug terms:cortiazem retarddiltiazemunclassified drug
EMTREE medical terms:articlecomplex formationdrug determinationspectrophotometry
MeSH:Chromatography, Thin LayerDiltiazemSpectrophotometryTablets

Chemicals and CAS Registry Numbers:

diltiazem, 33286-22-5, 42399-41-7;

Diltiazem, 42399-41-7; Tablets

Drug tradename:

  • cortiazem retard, inex, Yugoslavia

Manufacturers:

Drug manufacturer:

goedecke, Germany;

inex, Yugoslavia

  • ISSN: 0014827X
  • CODEN: FRMCE
  • Source Type: Journal
  • Original language: English
  • PubMed ID: 1503602
  • Document Type: Article

  Zivanov-Stakic, D.; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Dr. Subotica 8, Yugoslavia
© Copyright 2004 Elsevier B.V., All rights reserved.

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