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Journal of the Serbian Chemical SocietyVolume 63, Issue 11, 1998, Pages 841-844

The preparation of an isoxazole derivative of 4-hydroxycoumarin(Article)

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  • aCenter for Chemistry, ICTM, Njegoševa 12, 11001 Belgrade, Serbia
  • bFaculty of Science, Department of Chemistry, Radoja Domanovića 12, 34000 Kragujevac, Serbia
  • cFaculty of Chemistry, University of Belgrade, POB 158, YU-11001 Belgrade, Serbia

Abstract

A method for preparation of an isoxazole derivative of 4-hydroxycoumarin, 3-phenyl-5-(4-hydroxy-3-coumarinyl)-isoxazole has been described The reaction sequence includes addition of bromine to 3-cinnamoyl-4-hydroxycoumarin, and the subsequent treatment of the obtained dibromo derivative with 2 equivalents of sodium azide. Due to steric reasons, the azido group is introduced in the β-position with respect to the side chain carbonyl group, so that an isoxazole ring can be formed. The total yield of the reaction was 58%.

Author keywords

4-hydroxycoumarinAzidovinyl ketonesIsoxazole
  • ISSN: 03525139
  • CODEN: JSCSE
  • Source Type: Journal
  • Original language: English
  • Document Type: Article
  • Publisher: Serbian Chemical Society

  Krstić, L.; Center for Chemistry, ICTM, Njegoševa 12, Serbia
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