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Journal of Chromatography AVolume 798, Issue 1-2, 6 March 1998, Pages 173-177

High-performance liquid chromatographic assay of 8-hydroxyquinoline sulfate and its stability in immunobiological preparations(Conference Paper)

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  • aControl Department, TORLAK, Institute of Immunology and Virology, Vojvode Stepe 458, 11221 Belgrade, Serbia
  • bDept. of Pharmaceutical Chemistry, Faculty of Pharmacy, Vojvode Stepe 450, 11221 Belgrade, Serbia
  • cInstitute of Pharmacy of Serbia, Vojvode Stepe 458, 11221 Belgrade, Serbia

Abstract

Because of the ability of 8-hydroxyquinoline sulfate (8-HQS) to irreversibly bind metals from rubber stoppers, the stability of 8-HQS in tuberculin solutions was investigated. For the determination of 8-HQS, a simple and sensitive reversed-phase HPLC method with detection at 240 nm was developed and validated. Rapid decreases in concentrations of 8-HQS were found in samples stored in original vials which were exposed to different temperatures and vial positions.

Author keywords

Hydroxyquinoline sulfatePharmaceutical analysisStability studiesTuberculin

Indexed keywords

EMTREE drug terms:8 quinolinol sulfatetuberculin
EMTREE medical terms:conference paperdrug packagingdrug stabilitymetal bindingpriority journalreversed phase high performance liquid chromatographytemperature

Chemicals and CAS Registry Numbers:

8 quinolinol sulfate, 134-31-6, 14534-95-3, 3819-18-9; tuberculin, 92129-86-7

Manufacturers:

Drug manufacturer:

Fluka, Germany

  • ISSN: 00219673
  • CODEN: JCRAE
  • Source Type: Journal
  • Original language: English
  • DOI: 10.1016/S0021-9673(97)01085-6
  • PubMed ID: 9542139
  • Document Type: Conference Paper
  • Publisher: Elsevier B.V.

  Mihajlovic, A.; Control Department, TORLAK, Institute of Immunology and Virology, Vojvode Stepe 458, Serbia
© Copyright 2019 Elsevier B.V., All rights reserved.

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