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Mutation Research - Genetic Toxicology and Environmental MutagenesisVolume 588, Issue 2, 30 December 2005, Pages 152-157

Evaluation of genotoxic effects of Apitol® (cymiazole hydrochloride) in vitro by measurement of sister chromatid exchange(Article)

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  • aDepartment of Biology, Faculty of Veterinary Medicine, University of Belgrade, Bul. oslobodjenja 18, Belgrade 11000, Serbia
  • bDepartment of Animal Husbandry and Genetics, Faculty of Veterinary Medicine, University of Belgrade, Bul. oslobodjenja 18, Belgrade 11000, Serbia
  • cInstitute of Zoology, Faculty of Biology, University of Belgrade, Studentski trg 16, Belgrade 11000, Serbia

Abstract

Apitol®, with cymiazole hydrochloride as the active ingredient, is used in bee-keeping against the ectoparasitic mite Varroa destructor. The preparation was evaluated for genotoxicity in cultured human peripheral blood lymphocytes. Sister chromatid exchange, the mitotic index and the cell proliferation index were determined for three experimental concentrations of Apitol® (0.001, 0.01 and 0.1 mg/ml). All concentrations significantly (p < 0.001) increased the mitotic index (MI = 7.35 ± 0.18%, 8.31 ± 0.20% and 12.33 ± 0.25%, respectively), the proliferative index (PI = 1.83 ± 0.01, 1.84 ± 0.01 and 1.88 ± 0.02, respectively) and the frequency of sister chromatid exchange (SCE = 8.19 ± 1.81, 8.78 ± 1.80 and 13.46 ± 1.88, respectively), suggesting that cymiazole hydrochloride has genotoxic potential. © 2005 Elsevier B.V. All rights reserved.

Author keywords

AcaricideApitol® (cymiazole hydrochloride)GenotoxicHoneySister chromatid exchangeVarroa destructor

Indexed keywords

EMTREE drug terms:acaricidechloridecymiazolepyrrole derivativeunclassified drug
EMTREE medical terms:articlecell proliferationconcentration responsecontrolled studygenotoxicityhumanhuman cellhuman cell culturein vitro studylymphocyte culturemeasurementmitosis indexperipheral lymphocytepriority journalsister chromatid exchange
Species Index:AcariApoideaVarroa destructor

Chemicals and CAS Registry Numbers:

chloride, 16887-00-6

Funding details

Funding sponsor Funding number Acronym
143022

  • 1

    These studies were supported by the Serbian Ministry of Science and Environmental Protection, grant no. 143022.

  • ISSN: 13835718
  • CODEN: MRGMF
  • Source Type: Journal
  • Original language: English
  • DOI: 10.1016/j.mrgentox.2005.10.003
  • PubMed ID: 16309949
  • Document Type: Article
  • Publisher: Elsevier

  Stanimirovic, Z.; Department of Biology, Faculty of Veterinary Medicine, University of Belgrade, Bul. oslobodjenja 18, Serbia;
© Copyright 2019 Elsevier B.V., All rights reserved.

Cited by 29 documents

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ANTI-VARROA EFFICIENCY OF COUMAPHOS AND ITS INFLUENCE ON OXIDATIVE STRESS AND SURVIVAL OF HONEY BEES | EFIKASNOST KUMAFOSA PROTIV VAROE I NJEGOV UTICAJ NA OKSIDATIVNI STRES I PREŽIVLJAVANJE MEDONOSNE PČELE
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Taric, E. , Glavinic, U. , Vejnovic, B.
Oxidative stress, endoparasite prevalence and social immunity in bee colonies kept traditionally vs. Those kept for commercial purposes
(2020) Insects
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