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Evaluation of biomaterials as safe and effective therapies needs preclinical models to estimate their biologic potential. This paper investigates biocompatibility by the in vivo assessment of the muscle tissue reaction after implantation of the hidrothermally produced calciumhydroxyapatite. Specific attention has to be given to the synthesis technique which influences the stereology of the material and the behaviour of the material in living tissues. The synthesized powders of hydroxyapatite are preferentially carbonated hydroxyapatite of the B type in the form of agglomerates that accommodate two-modal size pores of 1.5-10 nm and 50-200 nm. The particles are built from crystallites of 8-22 nm in size, bind inside of the prime particles sized is between 10 and 63 nm. They form agglomerates of 200 nm in size and these were further clustered building up the biggest agglomerates of 5-20 μm. Biocompatibility assessment revealed that only mild to moderate inflammatory reaction was seen around the calciumhydroxyapatite implants. Calciumhydroxyapatite failed to show any substantional toxicity.