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Central European Journal of MedicineVolume 8, Issue 1, February 2013, Pages 41-44

Clear cell "sugar" tumor of the lung - Case report(Article)(Open Access)

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  • aPathology Department, Institute for Lung Diseases of Vojvodina, 21234 Sremska Kamenica, Serbia
  • bInstitute for Lung Diseases of Vojvodina, Clinic of Thoracic Surgery, 21234 Sremska Kamenica, Serbia
  • cRadiology Department, Institute for Lung Diseases of Vojvodina, 21234 Sremska Kamenica, Serbia
  • dDepartment for Pharmacology and Toxicology, Medical Faculty Novi Sad, Hajduk Veljkova 3, 21000 Novi Sad, Serbia

Abstract

Background: The clear cell "sugar" tumor of the lung is an extremely rare benign mesenchymal tumor. Aim: To report a case of the sugar tumor and discuss diagnostic differentiation of the tumor. Case report: A 53-year female presented with persisting cough. A CT scan revealed a round, 10 mm nodule located within the right lower lobe. The nodule was easily removed during thoracotomy. On the gross examination, the tumor was well circumscribed, and had a homogenous grayish-white appearance on the cut surface. The tumor consisted of round and oval cells with abundant clear cytoplasm, showing PAS pozitive abundant glycogen granules, which were removed by diastase pre-treatment before further staining with PAS. Immunohistochemical studies revealed the tumor cells were positive for HMB-45, vimentin, S-100 protein and very few cells for CD-117. The tumor cells were negative for αSMA, CK-7, AE1/AE3, CD-10, chromogranin and TTF-1. Conclusion: Based on the clinical, pathohistological and immunohistochemical data, the diagnosis of the primary clear cell sugar tumor of the lung was established. © 2012 Versita Warsaw and Springer-Verlag Berlin Heidelberg.

Author keywords

Clear cell pulmonary tumorSugar tumor

Indexed keywords

EMTREE drug terms:alpha smooth muscle actinamylasechromogranincommon acute lymphoblastic leukemia antigencytokeratin 7cytokeratin AE1cytokeratin AE3glycogenmonoclonal antibody HMB 45protein S 100stem cell factor receptorthyroid transcription factor 1vimentin
EMTREE medical terms:adultarticlecase reportcell shapeclear cell sugar tumor of the lungcomputer assisted tomographycoughingcytoplasmfemalefrozen sectionhistopathologyhospital dischargehumanhuman tissueimmunohistochemistrylung lobelung tumormicroscopyperiodic acid Schiff stainpriority journalthoracotomytumor celltumor localizationtumor volume

Chemicals and CAS Registry Numbers:

amylase, 9000-90-2, 9000-92-4, 9001-19-8; glycogen, 9005-79-2

  • ISSN: 18951058
  • Source Type: Journal
  • Original language: English
  • DOI: 10.2478/s11536-012-0049-1
  • Document Type: Article

  Kosjerina, Z.; Pathology Department, Institute for Lung Diseases of Vojvodina, Serbia;
© Copyright 2013 Elsevier B.V., All rights reserved.

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