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International Urology and NephrologyVolume 45, Issue 4, August 2013, Pages 1111-1119

High uric acid and low superoxide dismutase as possible predictors of all-cause and cardiovascular mortality in hemodialysis patients(Article)

  • Antunovic, T.,
  • Stefanovic, A.,
  • Ratkovic, M.,
  • Gledovic, B.,
  • Gligorovic-Barhanovic, N.,
  • Bozovic, D.,
  • Ivanisevic, J.,
  • Prostran, M.,
  • Stojanov, M.
  • View Correspondence (jump link)
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  • aCenter for Clinical Laboratory Diagnostics, Clinical Center of Montenegro, Podgorica, Montenegro
  • bDepartment of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11152 Belgrade, Serbia
  • cClinic for Urology and Nephrology, Clinical Center of Montenegro, Podgorica, Montenegro
  • dDepartment of Pharmacology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia

Abstract

Purpose: We investigated the role of serum uric acid (sUA) and superoxide dismutase (SOD) as predictive factors for mortality in hemodialysis (HD) patients. Methods: SOD, butyrylcholinesterase, and malondialdehyde were estimated spectrophotometrically and the other parameters by standard procedures. High-sensitive C-reactive protein was assayed by a sandwich ELISA method. Results: sUA among survivors (112.1 ± 13.82 μmol/L) was significantly lower than in deceased (160.8 ± 16.81 μmol/L, p < 0.001), while SOD was higher in survivors (31.8 ± 6.61 kU/L) than among deceased (20.2 ± 3.03, p < 0.05). Kaplan-Meier survival curves showed the greatest mortality risk in the highest tertile of basal sUA concentration (≥127.11 μmol/L, p < 0.001), and for SOD in the lowest tertile (≤23.83 kU/L, p < 0.05). Conclusion: Our results suggest that high sUA and low SOD may predict all-cause and cardiovascular mortality in HD patients. © 2012 Springer Science+Business Media, B.V.

Author keywords

Cardiovascular risk mortalityHemodialysisSuperoxide dismutaseUric acid

Indexed keywords

EMTREE drug terms:superoxide dismutaseuric acid
EMTREE medical terms:adultarticlecardiovascular mortalityenzyme blood levelfemalehemodialysishemodialysis patienthumanmajor clinical studymalemortalityprognosisprospective studyrisk assessmentrisk factorsurvivaluric acid blood level
MeSH:AgedBiological MarkersCardiovascular DiseasesCause of DeathCohort StudiesConfidence IntervalsEnzyme-Linked Immunosorbent AssayFemaleHumansKaplan-Meier EstimateKidney Failure, ChronicLogistic ModelsMaleMalondialdehydeMiddle AgedMultivariate AnalysisPredictive Value of TestsPrognosisProspective StudiesRenal DialysisSpectrophotometrySuperoxide DismutaseSurvival AnalysisUric Acid

Chemicals and CAS Registry Numbers:

superoxide dismutase, 37294-21-6, 9016-01-7, 9054-89-1; uric acid, 69-93-2

Funding details

Funding sponsor Funding number Acronym
Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja175023,175035MPNTR
Ministarstvo Prosvete, Nauke i Tehnološkog RazvojaMPNTR

  • 1

    Acknowledgments This work was supported by grants from the Ministry of Education and Science, Republic of Serbia (Projects No. 175023 and 175035).

  • ISSN: 03011623
  • CODEN: IURNA
  • Source Type: Journal
  • Original language: English
  • DOI: 10.1007/s11255-012-0233-x
  • PubMed ID: 22828740
  • Document Type: Article

  Stefanovic, A.; Department of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, Serbia;
© Copyright 2013 Elsevier B.V., All rights reserved.

Cited by 12 documents

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The association between the serum uric acid to creatinine ratio and all-cause mortality in elderly hemodialysis patients
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Foshati, S. , Askari, G. , Bagherniya, M.
Association between nutritional, inflammatory and oxidative status (NIOS) and risk of adverse outcomes in patients on haemodialysis (HD): the NIOS-HD prospective cohort study protocol
(2022) BMJ Open
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