Efficiency of sepiolite in broilers diet as uranium adsorbent(Article)
- aDepartment of Radiology and Radiation Hygiene, University of Belgrade, Bulevar Oslobodjenja 18, Belgrade, 11000, Serbia
- bDepartment of Veterinary Pathology, University of Belgrade, Bulevar Oslobodjenja 18, Belgrade, 11000, Serbia
- cUniversity of Belgrade, Karnegijeva 4, Belgrade, 11000, Serbia
- dInstitute for Technology of Nuclear and Other Mineral Row Materials, University of Belgrade, Bulevar Franš d‘Eperea 86, Belgrade, 11000, Serbia
- eDepartment of Economics and Statistics, University of Belgrade, Bulevar Oslobodjenja 18, Belgrade, 11000, Serbia
Abstract
The use of phosphate mineral products in animal nutrition, as a major source of phosphor and calcium, can lead to uranium entering the food chain. The aim of the present study was to determine the protective effect of natural sepiolite and sepiolite treated with acid for broilers after oral intake of uranium. The broilers were contaminated for 7 days with 25 mg/uranyl nitrate per day. Two different adsorbents (natural sepiolite and sepiolite treated with acid) were given via gastric tube immediately after the oral administration of uranium. Natural sepiolite reduced uranium distribution by 57 % in kidney, 80 % in liver, 42 % in brain, and 56 % in muscle. A lower protective effect was observed after the administration of sepiolite treated with acid, resulting in significant damage of intestinal villi in the form of shortening, fragmentation, and necrosis, and histopathological lesions on kidney in the form of edema and abruption of epithelial cells in tubules. When broilers received only sepiolite treated with acid (no uranyl nitrate), shortening of intestinal villi occurred. Kidney injuries were evident when uranium concentrations in kidney were 0.88 and 1.25 µg/g dry weight. It is concluded that adding of natural sepiolite to the diets of broilers can reduce uranium distribution in organs by significant amount without adverse side effects. © 2015, Springer-Verlag Berlin Heidelberg.
Indexed keywords
| Engineering controlled terms: | AdsorbentsChemical contaminationNitratesNutritionPhosphate mineralsToxicityUranium compounds |
|---|---|
| Engineering uncontrolled terms | Adverse side effectsBroilersHistopathologyOral administrationProtective effectsSepioliteUranium concentrationUranium distribution |
| Engineering main heading: | Uranium |
| EMTREE drug terms: | magnesium silicatemagnesium trisilicateuraniumuranyl nitrate |
| EMTREE medical terms: | adsorptionanalysisanimalanimal foodchemistrychickenintestineisolation and purificationmetabolismpHtime factor |
| MeSH: | AdsorptionAnimal FeedAnimalsChickensHydrogen-Ion ConcentrationIntestinesMagnesium SilicatesTime FactorsUraniumUranyl Nitrate |
Chemicals and CAS Registry Numbers:
magnesium silicate, 1343-88-0; magnesium trisilicate, 14987-04-3, 15501-74-3, 18307-23-8, 63800-37-3, 8014-97-9; uranium, 7440-61-1; uranyl nitrate, 10102-06-4, 36478-76-9;
Magnesium Silicates; magnesium trisilicate; Uranium; Uranyl Nitrate
Funding details
| Funding sponsor | Funding number | Acronym |
|---|---|---|
| Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja | 31003,TR 34013,TR 31003,451-03-2802/2013-16/160 | MPNTR |
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1
This work was supported by the Ministry of Education, Science and Technological Development of Serbia, in the frame of Innovation Project No. 451-03-2802/2013-16/160 and Projects No. TR 31003 and TR 34013.
- ISSN: 0301634X
- CODEN: REBPA
- Source Type: Journal
- Original language: English
- DOI: 10.1007/s00411-015-0589-2
- PubMed ID: 25652083
- Document Type: Article
- Publisher: Springer New York LLC
Mitrović, B.M.; Department of Radiology and Radiation Hygiene, University of Belgrade, Bulevar Oslobodjenja 18, Belgrade, Serbia
© Copyright 2016 Elsevier B.V., All rights reserved.
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