Antioxidant and enzyme-inhibitory activity of peppermint extracts and essential oils obtained by conventional and emerging extraction techniques(Article)
- aUniversity of Novi Sad, Faculty of Technology, Blvd. cara Lazara 1, Novi Sad, 21000, Serbia
- bUniversity of Novi Sad, Institute of Food Technology, Blvd. cara Lazara 1, Novi Sad, 21000, Serbia
- cDepartment of Biology, Science Faculty, Selcuk Unviersity, Campus, Konya, 42130, Turkey
- dUniversity of Belgrade, Institute of General and Physical Chemistry, Studentski trg 12/V, Belgrade, 11158, Serbia
Abstract
Peppermint is widely used medicinal plant with distinguished bioactive potential, therefore, the aim of present work was to develop novel peppermint extracts with high activity by application of traditional and emerging separation techniques. Conventional hydrodistillation and microwave-assisted hydrodistillation (MWHD) were applied for recovery of essential oil (EO), while organic solvent extraction using Soxhlet apparatus, microwave-assisted and ultrasound-assisted process and supercritical fluid extraction (SFE) were applied for non-selective recovery of peppermint lipophilic extracts. Extracts were characterized in terms of terpenoids profile with special emphasis on content of major compounds (mentol, menthone, isomenthol and eucalyptol). Antioxidant activity (DPPH, ABTS, CUPRAC, FRAP, chelating and phosphomolybdenum assay) and enzyme-inhibitory assays (acetylcholinesterase, butyrylcholinesterase, tyrosinase, amylase and glucosidase inhibition) were used for screening of peppermint bioactivity. MWHD was recognized as alternative for traditional process in EO recovery, while SFE extracts were useful for green production of solvent-free peppermint extracts rich in terpenoids and other lipophilic bioactives. © 2020 Elsevier Ltd
Indexed keywords
| Engineering controlled terms: | AntioxidantsBioactivityEffluent treatmentEnzyme activityEnzyme inhibitionLipidsPlant extractsRecoverySupercritical fluid extractionSupercritical fluids |
|---|---|
| Engineering uncontrolled terms | AcetylcholinesteraseAnti-oxidant activitiesButyrylcholinesteraseExtraction techniquesInhibitory activityMicrowave-assisted hydrodistillationSeparation techniquesSupercritical fluid extraction (SFE) |
| Engineering main heading: | Essential oils |
| EMTREE drug terms: | acarboseacetylcholinesteraseamylaseborneolcholinesterasecineoleessential oilgalantaminegallic acidglucosidaseisomenthonekojic acidlimonenelinaloolmentholmenthonemonophenol monooxygenasemyrceneneoisomentholneomentholorganic solventpara cymenepeppermintpolyphenol derivativerutosideterpenoidterpineneterpineolthymoltrolox Cunclassified drugacetylcholinesteraseantioxidantenzyme inhibitoressential oilplant extractpolyphenolterpene |
| EMTREE medical terms: | ABTS radical scavenging assayantioxidant activityArticlechelationchemical compositionchemical fingerprintingcontrolled studyDPPH radical scavenging assayenzyme inhibitionextractionferric reducing antioxidant power assayhydrodistillationin vitro studylipophilicityMentha piperitamicrowave assisted extractionseparation techniquesolvent extractionSoxhlet extractionsupercritical fluid extractionultrasound assisted extractionchemistryisolation and purificationMentha piperitametabolismmicrowave radiationprincipal component analysissupercritical fluid chromatographyultrasound |
| MeSH: | AcetylcholinesteraseAntioxidantsChromatography, Supercritical FluidEnzyme InhibitorsMentha piperitaMicrowavesOils, VolatilePlant ExtractsPolyphenolsPrincipal Component AnalysisSonicationTerpenes |
Chemicals and CAS Registry Numbers:
acarbose, 56180-94-0; acetylcholinesterase, 9000-81-1; amylase, 9000-90-2, 9000-92-4, 9001-19-8; borneol, 10385-78-1, 507-70-0; cholinesterase, 9001-08-5; cineole, 470-82-6, 55962-72-6; galantamine, 1953-04-4, 357-70-0; gallic acid, 149-91-7; glucosidase, 9033-06-1; isomenthone, 491-07-6; kojic acid, 501-30-4; limonene, 138-86-3, 5989-27-5; linalool, 78-70-6; menthol, 1490-04-6, 89-78-1, 15356-70-4, 2216-51-5, 98167-53-4; menthone, 10458-14-7, 8014-79-7, 89-80-5; monophenol monooxygenase, 9002-10-2; myrcene, 123-35-3; para cymene, 99-87-6; rutoside, 153-18-4, 22519-99-9; terpinene, 8013-00-1; terpineol, 8000-41-7, 98-55-5; thymol, 89-83-8; trolox C, 56305-04-5; polyphenol, 37331-26-3;
Acetylcholinesterase; Antioxidants; Enzyme Inhibitors; Oils, Volatile; Plant Extracts; Polyphenols; Terpenes
Manufacturers:
Drug manufacturer:
Sigma Aldrich, Germany
Funding details
| Funding sponsor | Funding number | Acronym |
|---|---|---|
| Provincial Secretariat for Science and Technological Development | PSSTD | |
| Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja | 200134,451-03-68/2020-14/200051,451-03-68/2020-14/200134 | MPNTR |
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1
The research is part of the project entitled \u201CDevelopment of system for precise control of microwave-assisted extraction parameters in order to increase yield and prevent degradation of target compounds\u201D (Project No. 114-451-2800/2016-02) and is financially supported by the Provincial secretariat for science and technological development, Autonomous Province of Vojvodina, Serbia . This study was financially supported by Ministry of Education, Science and Technological Development, Republic of Serbia ( 451-03-68/2020-14/200134 and 451-03-68/2020-14/200051 ).
- ISSN: 03088146
- CODEN: FOCHD
- Source Type: Journal
- Original language: English
- DOI: 10.1016/j.foodchem.2020.127724
- PubMed ID: 32795878
- Document Type: Article
- Publisher: Elsevier Ltd
Zeković, Z.; University of Novi Sad, Faculty of Technology, Blvd. cara Lazara 1, Novi Sad, Serbia;
© Copyright 2020 Elsevier B.V., All rights reserved.
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