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Applied Sciences (Switzerland)Volume 11, Issue 5, 1 March 2021, Article number 2049, Pages 1-12

Microfluidic platform for examination of effect of chewing xylitol gum on salivary pH, O2, and CO2(Article)(Open Access)

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  • aBioSense Institute, University of Novi Sad, Novi Sad, 21000, Serbia
  • bFaculty of Medicine, University of Novi Sad, Novi Sad, 21000, Serbia
  • cFaculty of Technical Sciences, University of Novi Sad, Novi Sad, 21000, Serbia

Abstract

Miniaturization of different measurement processes and a scaled-down approach open the possibility for rapid measurements with the small amounts of samples and reagents into a compact platform with integrated sensors and different measuring components. In this paper, we report a microfluidic approach for measurements of salivary pH, dissolved O2, and CO2 during chewing xylitol gum The study was done with the samples of 30 healthy volunteers who were chewing a xylitol gum, and the measurements were performed in the microfluidic (MF) chip with integrated commercial PreSens sensors. Xylitol exhibited a significant effect on the pH of saliva in terms of its initial drop, which was the most significant between the 5th and 10th minutes. The effect of xylitol on the amount of oxygen and carbon dioxide in saliva cannot be confirmed. The employed microfluidic platform was shown to be applicable and effective in the analysis of salivary biomarkers relevant to caries development. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Author keywords

CO2MicrofluidicsO2pHPMMASalivaXurographyXylitol

Funding details

Funding sponsor Funding number Acronym
Horizon 2020 Framework Programme
See opportunities by H2020		H2020
H2020 Marie Skłodowska-Curie Actions
See opportunities by MSCA		872370MSCA

  • 1

    This research has received funding from the European Union?s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement No. 872370.

  • ISSN: 20763417
  • Source Type: Journal
  • Original language: English
  • DOI: 10.3390/app11052049
  • Document Type: Article
  • Publisher: Multidisciplinary Digital Publishing Institute (MDPI)

  Podunavac, I.; BioSense Institute, University of Novi Sad, Novi Sad, Serbia;
© Copyright 2023 Elsevier B.V., All rights reserved.

Cited by 3 documents

Chandrasekharan, H.K. , Wlodarczyk, K.L. , MacPherson, W.N.
In-situ multicore fibre-based pH mapping through obstacles in integrated microfluidic devices
(2024) Scientific Reports
Goktas, H. , Agan, C.
Production of sucrose-free and probiotic chocolate pudding using xylitol in combination with Lacticaseibacillus rhamnosus GG and Saccharomyces boulardii
(2024) Journal of Food Measurement and Characterization
Podunavac, I. , Hinić, S. , Kojić, S.
Microfluidic approach for measurements of pH, O2, and CO2in Saliva
(2021) Sensors and Materials
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