Skip to main content
MoleculesVolume 26, Issue 9, 2021, Article number 2548

Pressurized-liquid extraction as an efficient method for valorization of thymus serpyllum herbal dust towards sustainable production of antioxidants(Article)(Open Access)

  Save all to author list
  • aFaculty of Technology, University of Novi Sad, Bulevar cara Lazara 1, Novi Sad, 21000, Serbia
  • bTUBITAK Marmara Research Centre, Institute of Chemical Technology, P.O. Box 21, Gebze, Kocaeli, 41470, Turkey
  • cInstitute of Food Technology, University of Novi Sad, Bulevar cara Lazara 1, Novi Sad, 21000, Serbia

Abstract

The aim of this study was to valorize Thymus serpyllum herbal dust, a particular fraction distinguished as an industrial waste from filter-tea production. Pressurized liquid extraction (PLE) was used with the aim of overcoming certain obstacles of conventional extraction techniques in terms of shortening extraction time, reducing solvent consumption and energy costs, using “green” solvents and obtaining high yield and quality products. In order to optimize PLE of T. serpyllum herbal dust, the preliminary screening of the independent variables in order to define the most influential parameters and their domain was done first. After the screening, the optimization study using the face-centered central composite experimental design (CCD) with response surface methodology (RSM) was implemented. Additionally, taking into account the high awareness of the positive influence of antioxidants on the human health and associating it with high content of polyphenolic compounds in various members of Lamiaceae family, PLE has proven to be a great approach for antioxidants recovery from T. serpyllum herbal dust. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Author keywords

Antioxidant activityMulti-response optimizationPolyphenolsPressurized-liquid extractionThymus serpyllum L

Indexed keywords

EMTREE drug terms:antioxidantphenol derivativeplant extractsolvent
EMTREE medical terms:chemistryhigh performance liquid chromatographyhumanisolation and purificationThymus (plant)
MeSH:AntioxidantsChromatography, High Pressure LiquidHumansPhenolsPlant ExtractsSolventsThymus Plant

Chemicals and CAS Registry Numbers:

Antioxidants; Phenols; Plant Extracts; Solvents

Funding details

Funding sponsor Funding number Acronym
Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja200222,451-03-9/2021-14/200134,451-03-68/2021-14/200222MPNTR

  • 1

    Funding: This research was funded by the Ministry of Education, Science and Technological Development, Republic of Serbia, grant number 451-03-9/2021-14/200134.

  • 2

    Acknowledgments: The authors would like to thank the Ministry of Education, Science and Technological Development, Republic of Serbia, for financial support (Project No. 451-03-9/2021-14/200134 and 451-03-68/2021-14/200222).

  • ISSN: 14203049
  • CODEN: MOLEF
  • Source Type: Journal
  • Original language: English
  • DOI: 10.3390/molecules26092548
  • PubMed ID: 33925545
  • Document Type: Article
  • Publisher: MDPI AG

  Pavlić, B.; Faculty of Technology, University of Novi Sad, Bulevar cara Lazara 1, Novi Sad, Serbia;
© Copyright 2021 Elsevier B.V., All rights reserved.

Cited by 21 documents

Ahmoda, R.A. , Pirković, A. , Milutinović, V.
Fumaria officinalis Dust as a Source of Bioactives for Potential Dermal Application: Optimization of Extraction Procedures, Phytochemical Profiling, and Effects Related to Skin Health Benefits
(2025) Plants
Teh, J.L. , Walvekar, R. , Ho, K.C.
Biolubricants from waste cooking oil: A review of extraction technologies, conversion techniques, and performance enhancement using natural antioxidants
(2025) Journal of Environmental Management
Aitbekov, R. , Zhamanbayeva, G. , Aralbaeva, A.
Pharmacological Composition of Thymus Serpyllum and Its Components
(2024) ES Food and Agroforestry
View details of all 21 citations
Inform me when this document is cited in Scopus:
Set citation alert Set citation feed
{"topic":{"name":"Flavonoid; Phenol; Antioxidant Capacity","id":42682,"uri":"Topic/42682","prominencePercentile":83.132545,"prominencePercentileString":"83.133","overallScholarlyOutput":0},"dig":"1dcf6c29abf34363c68275cc866191f4a18dadac7c2b885efde6ea0c5455aa75"}

SciVal Topic Prominence

Topic:
Prominence percentile: