Nanodesigned coatings obtained by plasma electrolytic oxidation of titanium implant and their cytotoxicity(Article)(Open Access)
- aSchool of Dentistry, University of Belgrade, Belgrade, Serbia
- bVinča Institute of Nuclear Sciences, University of Belgrade, Belgrade, Serbia
- cInstitute for Medical Research, Military Medical Academy, Medical Faculty MMA, University of Defence, Belgrade, Serbia
- dFaculty of Physics, University of Belgrade, Belgrade, Serbia
- eALBOS d.o.o, Belgrade, Serbia
Abstract
The titanium implant was treated with plasma electrolytic oxidation and subsequent ionic exchange and thermal treatment in order to obtain bioactive layer consisting of titanium oxide, calcium and sodium titanates and hydroxyapatite, as confirmed by X-ray diffraction (XRD). Scanning electron microscopy (SEM) revealed that the given method, besides corresponding phase composition, enables suitable nanotopology for cell attachment and proliferation. Cytotoxicity investigations by MTT, LDH and propidium iodide assays and light microscopy showed that these coatings were not toxic to L929 cells. © The Author(s) 2021.
Indexed keywords
| Engineering controlled terms: | ElectrolysisHydroxyapatiteIon exchangeOxidationScanning electron microscopySodium compoundsTitanium oxides |
|---|---|
| Engineering uncontrolled terms | Bioactive layersCalcium titanateImplantIonic exchangeLDH assayMTT assaysPlasma electrolytic oxidationSodium titanatesTitanium implantsX- ray diffractions |
| Engineering main heading: | Coatings |
| EMTREE drug terms: | calcium derivativehydroxyapatitesodium derivativetitanium dioxidebiocompatible coated materialtitanium |
| EMTREE medical terms: | animal cellArticlecoating (procedure)controlled studycytotoxicityequipment designmicroscopymouseMTT assayNCTC clone 929 cell linenonhumanoxidationpropidium iodide assayscanning electron microscopyX ray diffractionoxidation reduction reactionsurface property |
| MeSH: | Coated Materials, BiocompatibleDurapatiteMicroscopy, Electron, ScanningOxidation-ReductionSurface PropertiesTitaniumX-Ray Diffraction |
Chemicals and CAS Registry Numbers:
hydroxyapatite, 1306-06-5, 51198-94-8; titanium dioxide, 1317-70-0, 1317-80-2, 13463-67-7, 51745-87-0; titanium, 7440-32-6;
Coated Materials, Biocompatible; Durapatite; Titanium
Funding details
| Funding sponsor | Funding number | Acronym |
|---|---|---|
| MFVMA 10/13-15 | ||
| Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja | 172026 | MPNTR |
| Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja | MPNTR | |
| Academy of Military Medical Sciences | AMMS |
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1
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was supported by the Ministry of Education, Science and Technological Development of the Republic of Serbia (project number 172026) and Medical Faculty of the Military Medical Academy, University of Defence in Belgrade (project MFVMA 10/13-15).
- ISSN: 22808000
- Source Type: Journal
- Original language: English
- DOI: 10.1177/2280800018822252
- PubMed ID: 34783619
- Document Type: Article
- Publisher: SAGE Publications Ltd
Čolović, B.; Vinča Institute of Nuclear Sciences, University of Belgrade, Belgrade, Serbia;
© Copyright 2021 Elsevier B.V., All rights reserved.
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