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Macromolecular Rapid CommunicationsVolume 43, Issue 3, February 2022, Article number 2100656

Stimuli-Responsive Aggregation of High Molar Mass Poly(N,N-Diethylacrylamide)-b-Poly(4-Acryloylmorpholine) in Tetrahydrofuran(Article)(Open Access)

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  • aSchool of Chemistry, University of Glasgow, Glasgow, G12 8QQ, United Kingdom
  • bDepartment of Colloid Chemistry, Max Planck Institute of Colloids and Interfaces, Am Mühlenberg 1, Potsdam, 14476, Germany
  • cBioSense Institute, University of Novi Sad, Dr Zorana Djindjica 1, III-8, Novi Sad, 21000, Serbia
  • dScottish Centre for Macromolecular Imaging, University of Glasgow, Glasgow, G61 1QH, United Kingdom

Abstract

The self-assembly of block copolymers constitutes a timely research area in polymer science with implications for applications like sensing or drug-delivery. Here, the unprecedented aggregation behavior of high molar mass block copolymer poly(N,N-diethylacrylamide)-b-poly(4-acryloylmorpholine) (PDEA-b-PAM) (Mn>400 kg mol−1) in organic solvent tetrahydrofuran (THF) is investigated. To elucidate the aggregation, dynamic light scattering, cryo-transmission electron microscopy, and turbidimetry are employed. The aggregate formation is assigned to the unprecedented upper critical solution temperature behavior of PAM in THF at elevated concentrations (> 6 wt.%) and high molar masses. Various future directions for this new thermo-responsive block copolymer are envisioned, for example, in the areas of photonics or templating of inorganic structures. © 2021 The Authors. Macromolecular Rapid Communications published by Wiley-VCH GmbH.

Author keywords

block copolymershigh molecular weightreversible deactivation radical polymerizationself-assemblystimuli responsive polymers

Indexed keywords

Engineering controlled terms:Drug deliveryFunctional polymersHigh resolution transmission electron microscopyLight scatteringLight transmissionOrganic solventsSelf assembly
Engineering uncontrolled termsBlock co polymersHigh molecular weightPolymer scienceRapid communicationResearch areasReversible deactivation radical polymerizationStimuli-responsiveStimuli-responsive polymerTetra-hydrofuranTetrahydrofurans
Engineering main heading:Block copolymers
EMTREE drug terms:4-acryloylmorpholineacrylamide derivativefuran derivativemorpholine derivativepoly(N,N-diethylacrylamide)polymer
EMTREE medical terms:micelle
MeSH:AcrylamidesFuransMicellesMorpholinesPolymers

Chemicals and CAS Registry Numbers:

4-acryloylmorpholine; Acrylamides; Furans; Micelles; Morpholines; poly(N,N-diethylacrylamide); Polymers

Funding details

Funding sponsor Funding number Acronym
University of Glasgow
See opportunities
UK Research and InnovationUKRI
Medical Research Council
See opportunities by MRC		MC_PC_17135MRC
Scottish Funding CouncilMC_UU_12014/7,H17007SFC
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
See opportunities by SNF		P2GEP2_181528,181528SNF
Deutsche Forschungsgemeinschaft
See opportunities by DFG		SCHM 3282/3‐1DFG

  • 1

    The authors acknowledge Marlies Gr?wert and Sascha Prentzel for the help with SEC measurements and Antje V?lkel for DSC measurements. A.P. and B.S. acknowledge funding from the University of Glasgow and the German Research Foundation (grant no. SCHM 3282/3-1). M.P. acknowledges financial support from the Swiss National Science Foundation (project no. P2GEP2_181528). The authors acknowledge the Scottish Centre for Macromolecular Imaging (SCMI) for access to cryo-EM instrumentation, funded by the Medical Research Council (MC_PC_17135) and Scottish Funding Council (H17007). D.B. acknowledges financial support from Medical Research Council (MC_UU_12014/7). After initial online publication, the second affiliation of M.P. was corrected, as was the first affiliation of M.C. and D.B., on November 29, 2021. The editorial office apologizes for any inconvenience caused.

  • 2

    The authors acknowledge Marlies Gr\u00E4wert and Sascha Prentzel for the help with SEC measurements and Antje V\u00F6lkel for DSC measurements. A.P. and B.S. acknowledge funding from the University of Glasgow and the German Research Foundation (grant no. SCHM 3282/3\u20101). M.P. acknowledges financial support from the Swiss National Science Foundation (project no. P2GEP2_181528). The authors acknowledge the Scottish Centre for Macromolecular Imaging (SCMI) for access to cryo\u2010EM instrumentation, funded by the Medical Research Council (MC_PC_17135) and Scottish Funding Council (H17007). D.B. acknowledges financial support from Medical Research Council (MC_UU_12014/7).

  • ISSN: 10221336
  • CODEN: MRCOE
  • Source Type: Journal
  • Original language: English
  • DOI: 10.1002/marc.202100656
  • PubMed ID: 34783099
  • Document Type: Article
  • Publisher: John Wiley and Sons Inc

  Schmidt, B.V.K.J.; School of Chemistry, University of Glasgow, Glasgow, United Kingdom;
© Copyright 2022 Elsevier B.V., All rights reserved.

Cited by 5 documents

Bayliss, N. , Schmidt, B.V.K.J.
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Poly(N-acryloylmorpholine) Nanogels as Promising Materials for Biomedical Applications: Low Protein Adhesion and High Colloidal Stability
(2023) ACS Applied Polymer Materials
Bayliss, N. , Yilmaz, G. , Plucinski, A.
Thermoresponsive behaviour of poly(N,N-diethylacrylamide) in aqueous two-phase systems
(2023) Polymer Chemistry
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