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International Journal of Molecular SciencesVolume 23, Issue 7, April-1 2022, Article number 3760

Decoding the Bell-Shaped Calcium Spikes in Phosphorylation Cycles of Flagella(Article)(Open Access)

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  • aFaculty of Technical Sciences, University of Novi Sad, Novi Sad, 21000, Serbia
  • bSerbian Academy of Sciences and Arts, Belgrade, 11000, Serbia
  • cDepartment of Physics, University of Alberta, Edmonton, AB T6G 2R3, Canada

Abstract

We investigate the messenger role of calcium ions implicated in the regulation of wave-like bending dynamics of flagella. The emphasis is on microtubules of flagellar axoneme serving as nonlinear transmission lines for bell-shaped spikes of calcium ions. The calcium sensitive proteins, such as calmodulin, exhibit activation dependence on the spike train frequency and amplitude. Here, we analyze a Ca2+ decoding module IDA-I1 whose activity is controlled by Ca2+ activated kinase. We find that trains of Ca2+ spikes are advantageous compared to a constant rise in Ca2+ concentration as being more efficient and much less prone to noisy fluctuations. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.

Author keywords

AxonemeCalcium spike signalingDynein motorsFlagellumMicrotubule

Indexed keywords

EMTREE drug terms:axonemal dyneincalcium binding proteincalcium ioncalmodulinprotein IDA I1protein kinaseprotein kinase Cunclassified drugcalciumdynein adenosine triphosphataseion
EMTREE medical terms:Articleaxonemecalcium cell levelcalcium signalingcontrolled studyflagellumhumanmicrotubuleprotein phosphorylationregulatory mechanismcalcium intakecalcium signalingflagellummetabolismphosphorylationphysiology
MeSH:AxonemeCalciumCalcium SignalingCalcium, DietaryDyneinsFlagellaIonsMicrotubulesPhosphorylation

Chemicals and CAS Registry Numbers:

calcium ion, 14127-61-8; protein kinase, 9026-43-1; protein kinase C, 141436-78-4; protein kinase C theta; serine threonine protein kinase D2; calcium, 7440-70-2, 14092-94-5; dynein adenosine triphosphatase;

Calcium; Calcium, Dietary; Dyneins; Ions

Funding details

  • 1

    Funding: This research was funded by Department of Fundamental Sciences at Faculty of Technical Sciences at University of Novi Sad within the project “Application of Fundamental Disciplines in Technical and Information Sciences”.

  • ISSN: 16616596
  • Source Type: Journal
  • Original language: English
  • DOI: 10.3390/ijms23073760
  • PubMed ID: 35409111
  • Document Type: Article
  • Publisher: MDPI

  Tuszynski, J.; Department of Physics, University of Alberta, Edmonton, AB, Canada;
© Copyright 2022 Elsevier B.V., All rights reserved.

Cited by 1 document

Satarić, M.V. , Nemeš, T. , Zdravković, S.
Calcium messages in flagella are faster than messenger particles
(2023) BioSystems
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