

Hypertrophic cardiomyopathy is a congenital or acquired disorder of the heart muscle, which is clinically manifested by symmetrical or asymmetric hypertrophy of the left and/or right ventricle in the absence of any other cause of hypertrophy. The goal of this research was to develop a finite element model of the electrical activity of the heart embedded in the torso and use it to simulate healthy and ischemic event. Heart model geometry included seven different regions. A monodomain model of a modified FitzHugh-Nagumo model of the cardiac cell was used. Six electrodes are positioned at the chest to model the precordial leads and the results are compared with real clinical measurements. An inverse ECG method was used to optimize potential on the heart. A whole heart electrical activity in the torso-embedded environment, with spontaneous initiation of activation in the sinoatrial node, incorporating a specialized conduction system with heterogeneous action potential morphologies throughout the heart was presented. A body surface potential maps in a healthy subject during progression of ventricular activation in nine sequences. An electro model coupled with a mechanical model with linear elastic and orthotropic material model based on Holzapfel experiments was also presented. © 2022 Elsevier Inc. All rights reserved.
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