The Application of Ultrasonic Waves and Microwaves to Improve Antihyperglycaemic and Antimicrobial Activities of Marrubium vulgare Extracts(Article)(Open Access)
- aFaculty of Technology, University of Novi Sad, Novi Sad, 21000, Serbia
- bInstitute of Food Technology, University of Novi Sad, Novi Sad, 21000, Serbia
- cFaculty of Sciences, University of Novi Sad, Novi Sad, 21000, Serbia
- dInstitute for Medicinal Plants Research Dr. Josif Pančić, Belgrade, 11000, Serbia
Abstract
Having scarce information about ultrasound assisted extraction (UAE) and microwave assisted extraction (MAE) of white horehound (Marrubium vulgare L.), the idea has emerged to determine the optimal process parameters for the maximization of polyphenols and to compare the efficiency of these green extraction technologies. The optimal UAE parameters are temperature of 73.6 °C, extraction time of 40 min and ultrasound power of 30.3 W/L, while the optimal MAE parameters are 63.8% ethanol, extraction time of 15 min and microwave power of 422 W. Extract obtained at optimal UAE parameters shows the highest antihyperglycemic activity (α-amylase inhibition: 50.63% and α-glucosidase inhibition: 48.67%), which can potentially be explained by the presence of chlorogenic acid and quercetin, which were not identified in the macerates. The most sensitive bacterial strain to optimal ultrasonic extract is Bacillus cereus, whereas the most sensitive fungal strain is Saccharomyces cerevisiae. © 2022 by the authors.
Indexed keywords
| EMTREE drug terms: | acarbosealpha glucosidaseamylaseamylase inhibitorantidiabetic agentcatechinchlorogenic acidessential oilferulic acidflavonoidflavonolgallic acidkaempferolluteolinmarrubium vulgare extractphenolphytochemicalplant extractpolyphenolquercetinunclassified drug |
|---|---|
| EMTREE medical terms: | antidiabetic activityantimicrobial activityantioxidant activityArticleBacillus cereusBacillus subtilisbacterial strainCandida albicanscontrolled studyDPPH radical scavenging assayEC50Escherichia coliexperimental designextraction timeferric reducing antioxidant power assayfungal strainhigh performance liquid chromatographyIC50Klebsiella pneumoniaeMicrococcus luteusmicrowave assisted extractionmicrowave radiationnonhumanparticle sizeProteus mirabilisPseudomonas aeruginosaSaccharomyces cerevisiaeSoxhlet extractionStaphylococcus aureusStaphylococcus epidermidisultrasoundultrasound assisted extractionultraviolet spectrophotometry |
Chemicals and CAS Registry Numbers:
acarbose, 56180-94-0; alpha glucosidase, 9001-42-7; amylase, 9000-90-2, 9000-92-4, 9001-19-8; catechin, 13392-26-2, 154-23-4; chlorogenic acid, 327-97-9; ferulic acid, 1135-24-6, 24276-84-4; flavonol, 577-85-5; gallic acid, 149-91-7; kaempferol, 520-18-3; luteolin, 491-70-3; phenol, 108-95-2, 3229-70-7; polyphenol, 37331-26-3; quercetin, 117-39-5
Device tradename:
- Agilent 1200, Agilent, United States,
- NN-E201W, Panasonic, Japan,
- T80
Manufacturers:
Device manufacturer:
Panasonic, Japan;
Agilent, United States
Funding details
| Funding sponsor | Funding number | Acronym |
|---|---|---|
| Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja | 200134,451-03-68/2022-14/200134,451-03-68/2022-14/200125 | MPNTR |
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1
This research was funded by the Program of Ministry of Education, Science and Technological Development of Republic of Serbia; Projects No. 451-03-68/2022-14/200134 and No. 451-03-68/2022-14/200125.
- ISSN: 20796382
- Source Type: Journal
- Original language: English
- DOI: 10.3390/antibiotics11111475
- Document Type: Article
- Publisher: MDPI
Vidović, S.; Faculty of Technology, University of Novi Sad, Novi Sad, Serbia;
© Copyright 2022 Elsevier B.V., All rights reserved.
Cited by 2 documents
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