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Advanced Optical MaterialsVolume 11, Issue 3, 3 February 2023, Article number 2202366

Mn5+ Lifetime-Based Thermal Imaging in the Optical Transparency Windows Through Skin-Mimicking Tissue Phantom(Article)(Open Access)

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  • aInstitute of Low Temperature and Structure Research, Polish Academy of Sciences, Okólna 2, Wroclaw, 50–422, Poland
  • bNanomaterials for Bioimaging Group (nanoBIG), Materials Physics Department, Facultad de Ciencias, Autonomous University of Madrid, C/ Francisco Tomás y Valiente 7, Madrid, 28049, Spain
  • cNanomaterials for Bioimaging Group (nanoBIG), Department of Applied Physics, Facultad de Ciencias, Autonomous University of Madrid, C/ Francisco Tomás y Valiente 7, Madrid, 28049, Spain
  • dNanomaterials for Bioimaging Group (nanoBIG), Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Hospital Ramón y Cajal, Ctra. De Colmenar Viejo km 9.100, Madrid, 28034, Spain
  • eCentre of Excellence for Photoconversion, Vinča Institute of Nuclear Sciences – National Institute of the Republic of Serbia, University of Belgrade, P.O. Box 522, Belgrade, 11001, Serbia

Abstract

Lifetime-based luminescence thermometry has been shown to enable accurate deep-tissue monitoring of temperature changes – even at the in vivo level – in a minimally invasive way. However, major limiting factors to the performance of this approach are short lifetimes and poor brightness. These are characteristics, respectively, of semiconductor nanocrystals and lanthanide-doped nanoparticles, of which most luminescent nanothermometers are made. To address these limitations, the composition of luminescent nanothermometers co-doped with transition metal (Mn5+) and Er3+ ions are designed and optimized. The salient features of these nanothermometers are strong, near-infrared emission and long, temperature-dependent photoluminescence lifetime. The potential of these luminescent nanophosphors for thermal sensing is then showcased by monitoring a thermal gradient using a one-of-a-kind piece of equipment designed for lifetime-based luminescence thermometry measurements. The combination of the newly developed nanothermometers and the custom-made instrument allows for obtaining 2D thermal maps both in the absence and presence of tissue phantoms mimicking the optical properties of the skin. The results presented in this study thus provide credible foundations for the deployment of lifetime-based thermometry for accurate deep-tissue thermal mapping at the preclinical level. © 2022 The Authors. Advanced Optical Materials published by Wiley-VCH GmbH.

Author keywords

Ba 3(VO 4) 2lifetimeluminescence thermometrymanganesenear-infraredthermal imaging

Indexed keywords

Engineering controlled terms:Infrared devicesInfrared imagingLuminescenceOptical propertiesPhantomsThermometersTissue
Engineering uncontrolled termsBa 3(VO 4) 2LifetimeLuminescence thermometryNanothermometerNear InfraredNear-infraredOptical transparencyTemperature changesThermal-imagingTissue phantom
Engineering main heading:Manganese

Funding details

Funding sponsor Funding number Acronym
2021/0427,IMP21_A4
Comunidad de MadridSI3/PJI/2021‐00211
European Cooperation in Science and TechnologyCA17140COST
Instituto de Salud Carlos IIIPI19/00565ISCIII
Ministerio de Ciencia e InnovaciónPID2019‐106211RB‐I00,PID2020‐118878RB‐I00MICINN
Narodowa Agencja Wymiany AkademickiejNAWA

  • 1

    WM. P. acknowledges the financial support from the Bekker NAWA Programme BPN/BEK/2021/1/00029 funded by the Polish National Agency for Academic Exchange. Additional funding was provided by the Spanish Ministerio de Ciencia e Innovación projects PID2019‐106211RB‐I00 and PID2020‐118878RB‐I00, by the Instituto de Salud Carlos III (PI19/00565), by the Comunidad Autónoma de Madrid project SI3/PJI/2021‐00211 and network S2017/BMD3867 RENIM‐CM, co‐financed by the European structural and investment fund, and the Fundación para la Investigación Biomédica del Hospital Universitario Ramón y Cajal project IMP21_A4 (2021/0427), as well as COST action CA17140.

  • ISSN: 21951071
  • Source Type: Journal
  • Original language: English
  • DOI: 10.1002/adom.202202366
  • Document Type: Article
  • Publisher: John Wiley and Sons Inc

  Piotrowski, W.M.; Institute of Low Temperature and Structure Research, Polish Academy of Sciences, Okólna 2, Wroclaw, Poland;
  Marciniak, L.; Institute of Low Temperature and Structure Research, Polish Academy of Sciences, Okólna 2, Wroclaw, Poland;
© Copyright 2023 Elsevier B.V., All rights reserved.

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