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MathematicsVolume 10, Issue 24, December 2022, Article number 4791

Chaotic Model of Brownian Motion in Relation to Drug Delivery Systems Using Ferromagnetic Particles(Article)(Open Access)

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  • aFaculty of Medicine, University of Banja Luka, Save Mrkalja 14, Banja Luka, 78000, Bosnia and Herzegovina
  • bFaculty of Engineering, University of Kragujevac, Sestre Janjic 6, Kragujevac, 34000, Serbia
  • cInstitute for Information Technologies—National Institute of the Republic of Serbia, University of Kragujevac, Jovana Cvijica bb, Kragujevac, 34000, Serbia

Abstract

Deterministic and stochastic models of Brownian motion in ferrofluids are of interest to researchers, especially those related to drug delivery systems. The Brownian motion of nanoparticles in a ferrofluid environment was theoretically analyzed in this research. The state of the art in clinical drug delivery systems using ferromagnetic particles is briefly presented. The motion of the nanoparticles in an external field and as a random variable is elaborated by presenting a theoretical model. We analyzed the theoretical model and performed computer simulation by using Maple software. We used simple low-dimensional deterministic systems that can exhibit diffusive behavior. The ferrofluid in the gravitational field without the presence of an external magnetic field in the xy plane was observed. Control parameter p was mapped as related to the fluid viscosity. Computer simulation showed that nanoparticles can exhibit deterministic patterns in a chaotic model for certain values of the control parameter p. Linear motion of the particles was observed for certain values of the parameter p, and for other values of p, the particles move randomly without any rule. Based on our numerical simulation, it can be concluded that the motion of nanoparticles could be controlled by inherent material properties and properties of the surrounding media, meaning that the delivery of drugs could possibly be executed by a ferrofluid without an exogenous power propulsion strategy. However, further studies are still needed. © 2022 by the authors.

Author keywords

Brownian motionchaotic modelexogenous power propulsion strategyferrofluidtargeted drug delivery

Funding details

Funding sponsor Funding number Acronym
European Institute of Innovation and TechnologyEIT
European Commission
See opportunities by EC
EC
UK Research and Innovation105169UKRI
  • 1

    This paper is funded through the EIT\u2019s HEI Initiative SMART-2M project, supported by EIT RawMaterials, funded by the European Union.

  • ISSN: 22277390
  • Source Type: Journal
  • Original language: English
  • DOI: 10.3390/math10244791
  • Document Type: Article
  • Publisher: MDPI

  Živić, F.; Faculty of Engineering, University of Kragujevac, Sestre Janjic 6, Kragujevac, Serbia;
© Copyright 2022 Elsevier B.V., All rights reserved.

Cited by 1 document

Chen, J. , An, R. , Shu, L.
STUDY ON MOTION OF MULTI-COMPONENT FERROMAGNETIC PARTICLES WITH MODIFIED MAGNETIZATION MODEL | 修正磁化模型的多组分铁磁性颗粒运动研究
(2024) Lixue Xuebao/Chinese Journal of Theoretical and Applied Mechanics
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