Poly(methacrylic acid)/gelatin interpenetrating network hydrogels reinforced by nano-structured hydroxyapatite particles—improved drug delivery systems(Article)
- aInnovation Center of Faculty of Technology and Metallurgy, Belgrade, Serbia
- bDepartment of Biochemical Engineering and Biotechnology, Faculty of Technology and Metallurgy, University of Belgrade, Belgrade, Serbia
- cInstitute of Physiology and Biochemistry “Ivan Djaja”, Faculty of Biology, University of Belgrade, Belgrade, Serbia
- dDepartment of Inorganic Chemical Technology, Faculty of Technology and Metallurgy, University of Belgrade, Belgrade, Serbia
Abstract
Novel poly(methacrylic acid)/gelatin (PMAG) interpenetrating networks reinforced by different amounts of nanostructured particles of hydroxyapatite (HA) (HA/polymer weight ratios from 0% to 40%) were synthesized. The introduction of HA significantly enhanced mechanical properties, but slightly reduced swelling ability, pH sensibility and porosity. The increase of HA/polymer ratio to 40% increased the compressive strength from 29.83 (pure PMAG hydrogel) to 68.16 kPa. Drug release behavior investigated in simulated physiological conditions, using ciprofloxacin (hydrophilic) and oxaprozin (hydrophobic), demonstrated different drug release kinetics. In vitro antimicrobial testing demonstrated bactericidal and fungicidal activity of the drug-loaded hydrogels against E. coli, S. aureus and C. albicans. © 2023 Taylor & Francis Group, LLC.
Indexed keywords
| Engineering controlled terms: | AntibioticsCompressive strengthControlled drug deliveryEscherichia coliHydrogelsInterpenetrating polymer networksReinforcementTargeted drug delivery |
|---|---|
| Engineering uncontrolled terms | CiprofloxacinDrug-delivery systemsGelatinHydroxyapatite particlesNano-structuredNanostructured particlesOxaprozinPoly(methacrylic acid)Polymer weightsPolymethacrylic acid |
| Engineering main heading: | Hydroxyapatite |
Funding details
| Funding sponsor | Funding number | Acronym |
|---|---|---|
| University of Belgrade | ||
| Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja | 451-03-68/2022-14/200135,451-03-68/2022-14/200178,451-03-68/2022-14/200287,451-03-9/2021-14/200026 | MPNTR |
| Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja | MPNTR | |
| Magyar Tüdőgyógyász Társaság | MTT |
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1
The authors would like to acknowledge the financial support of the Ministry of Education, Science and Technological Development of the Republic of Serbia [Contract Nos. 451-03-68/2022-14/200287, 451-03-68/2022-14/200135, 451-03-9/2021-14/200026 and 451-03-68/2022-14/200178]. The authors acknowledge Biljana Bozic from the Faculty of Biology, University of Belgrade, for the valuable help in the MTT assay.
- ISSN: 00914037
- CODEN: IJPMC
- Source Type: Journal
- Original language: English
- DOI: 10.1080/00914037.2022.2164281
- Document Type: Article
- Publisher: Taylor and Francis Ltd.
Ugrinovic, V.; Innovation Center of Faculty of Technology and Metallurgy, Karnegijeva 4, Belgrade, Serbia;
© Copyright 2024 Elsevier B.V., All rights reserved.
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