On the synthesis of 3-cyano-6-hydroxy-4-methyl-2-pyridone at room temperature(Article)(Open Access)
[O SINTEZI 3-CIJANO-6-HIDROKSI-4-METIL-2-PIRIDONA NA SOBNOJ TEMPERATURI]
- aInstitute of Technical Sciences of the Serbian Academy of Sciences and Arts, Belgrade, Serbia
- bUniversity of Belgrade, Faculty of echnology and Metallurgy, Belgrade, Serbia
Abstract
Milling of cyanoacetamide and acetoacetic ester as reactants, in the presence of KOH as the catalyst and ethanol as a viscous control agent (VCA) was performed in a planetary ball mill with the goal of investigating the effect of mechanochemical treatment for the synthesis of 3-cyano-6-hydroxy-4-methyl-2-pyridone at room temperature. The mechanochemical synthesis was performed under various milling parameters, i.e. milling time up to 4 h, number and size of balls, angular velocity as well as molar ratio of reactants and the amount of catalyst. The obtained product was characterized by m.p., UV, IR and NMR data. It was fond that the dominant process parameter is the milling time while others are of less importance. The highest isolated yield after milling was up to 56%. The combination of milling and aging increase yield over 60%. © 2019, Engineers Society for Corrosion. All rights reserved.
Funding details
| Funding sponsor | Funding number | Acronym |
|---|---|---|
| Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja | 172013,45001 | MPNTR |
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Acknowledgment The authors gratefully acknowledge the financial support from the Ministry of Education, Science and Technological Development of the Republic of Serbia [grant numbers: 172013 and 45001].
- ISSN: 03519465
- Source Type: Journal
- Original language: English
- DOI: 10.5937/zasmat1903229Z
- Document Type: Article
- Publisher: Engineers Society for Corrosion
Mijin, D.Ž.; University of Belgrade, Faculty of echnology and Metallurgy, Belgrade, Serbia;
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