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Chemical CommunicationsVolume 59, Issue 29, 9 March 2023, Pages 4300-4303

Paper card-like electrochemical platform as a smart point-of-care device for reagent-free glucose measurement in tears(Article)(Open Access)

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  • aDepartment of Chemical Science and Technologies, University of Rome ‘‘Tor Vergata’’, via della Ricerca Scientifica 1, Rome, 00133, Italy
  • bSENSE4MED, Via Bitonto 139, Rome, 00133, Italy
  • cFaculty of Technical Sciences, University of Novi Sad, Novi Sad, 21000, Serbia
  • dOphthalmology Unit, Department of experimental medicine and surgery, University of Rome “Tor Vergata”, Rome, Italy

Abstract

This communication describes the development of polyvinyl chloride electrochemical system in which a paper layer loaded with reagents is inserted into the device, demonstrating a new concept of a paper card-like pad for a reagent-free and easy measurement of the target analyte in solution. This device detects glucose in artificial tears in the range of 0.2-2 mM with a detection limit of 50 μM by simply adding the artificial tears to the paper card-like pad. The novel configuration goes beyond the state of the art, widening the application range of paper in the design of smart analytical devices. © 2023 The Royal Society of Chemistry.

Indexed keywords

Engineering controlled terms:Analytic equipmentChlorine compoundsGlucosePaper
Engineering uncontrolled termsArtificial tearsDetection limitsElectrochemical platformsElectrochemical systemsGlucose measurementsMeasurements ofPoint of careReagent-freeState of the artTarget analytes
Engineering main heading:Polyvinyl chlorides
EMTREE drug terms:artificial tearferric ferrocyanideglucosehydrogen peroxidepolyvinylchloridereagentdyes, reagents, indicators, markers and buffersglucose
EMTREE medical terms:Articlecalibrationconcentration (parameter)controlled studycyclic voltammetrydispersionelectrochemical detectionlacrimal fluidlimit of detectionpoint of care testingreliabilityelectrochemical analysispaperpoint of care system
MeSH:Electrochemical TechniquesGlucoseIndicators and ReagentsLubricant Eye DropsPaperPoint-of-Care Systems

Chemicals and CAS Registry Numbers:

ferric ferrocyanide, 12240-15-2, 14038-43-8, 14433-93-3, 14460-02-7; glucose, 50-99-7, 84778-64-3, 8027-56-3; hydrogen peroxide, 7722-84-1; polyvinylchloride, 9002-86-2;

Glucose; Indicators and Reagents; Lubricant Eye Drops

  • ISSN: 13597345
  • CODEN: CHCOF
  • Source Type: Journal
  • Original language: English
  • DOI: 10.1039/d2cc06561d
  • PubMed ID: 36928485
  • Document Type: Article
  • Publisher: Royal Society of Chemistry

  Arduini, F.; Department of Chemical Science and Technologies, University of Rome ‘‘Tor Vergata’’, via della Ricerca Scientifica 1, Rome, Italy;
© Copyright 2023 Elsevier B.V., All rights reserved.

Cited by 8 documents

Karim, Z. , Khan, M.J. , Hussain, A.
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Internet of Things enabled open source assisted real-time blood glucose monitoring framework
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Elumalai, P.N.N. , Thimmarayappa, C.C. , Talebi, S.
Evaluation of a same-metal PCB-based three-electrode system via impedance studies using potassium ferricyanide
(2024) RSC Advances
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