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Print nonuniformity is the variation of optical density (reflection) on the print and can occur in several different types that can be classified into two basic groups: random and systematic variations. This article examines two types from each group of variations that are most commonly found in digital printing systems: blotches and streaks, where amplitude and size were varied. Three most commonly used methods for measuring the print nonuniformity were used: Grey Level Co-occurrence Matrix (GLCM), ISO 13660 and Integration (also Improved Integration) method. The results obtained by measuring were compared with a visual assessment to find the link between objective and subjective analysis and to define and determine which method/parameter is the best for the measurement of which type of print (non)uniformity. The obtained results indicate the possibility of selecting the measurement parameter, but that the choice of the parameter depends on the type of nonuniformity. It is concluded that in the case of the GLCM method, the entropy and energy parameters are strongly related to the visual assessment for all three sets of samples. These parameters can be used regardless of the type of nonuniformity. The ISO G parameter can be used to measure both graininess and mottling, while the ISO M parameter is only suitable for measuring mottling. Integration method could be used to measure systematic error. On the basis of conclusions of the research, it is possible to propose the development of an industrially applicable solution for measuring print nonuniformity of digitally printed samples. © 2023 Society of Dyers and Colourists.