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This study presents a systematic redesign of a microfluidic compact disc (CD) that showcases six distinct chamber subsystems. This type of a subsystem is specifically designed to facilitate concurrent sample loading, mixing, and analysis. Departing from the original focus on saliva as a diagnostic medium, this study shifts towards the utilization of sweat. Modifications are made to the electrode designs to ensure accurate comparison and electrochemical analysis. The primary aim of this investigation is to explore the variations in electrochemical properties that occur within dilution of sweat samples as well as varying pH levels. This is important as specimens can vary greatly in their composition and complexity. By contrasting the electrochemical impedance characteristics of sweat samples with different pH levels, this study aims to shed light on potential foundations for the early diagnosis and monitoring of skin diseases. Preliminary findings from this extension of the study reveal distinct conductance patterns. These findings provide valuable insights and further support the notion that the redesigned microfluidic CD platform possesses the capability for multiplex processes. This, in turn, paves the way for future research in the field of theranostics and the electrochemical analysis of diverse sweat compositions at the point of care. © 2024 IEEE.