Recent advances of bone tissue engineering: carbohydrate and ceramic materials, fundamental properties and advanced biofabrication strategies ‒ a comprehensive review(Review)
- aDepartment of Mechanical and Industrial Engineering, Qatar University, Doha, 2713, Qatar
- bBiomedical Research Center, Qatar University, Doha, 2713, Qatar
- cDepartment of Physics, University of Engineering and Technology, Lahore, 39161, Pakistan
- dOral and Maxillofacial Surgery Unit, School of Dental Sciences Universiti Sains Malaysia, Health Campus, Kubang Kerian Kota Bharu, Kelantan, 16150, Malaysia
- eOral and Maxillofacial Surgery Unit, Hospital Universiti Sains Malaysia, Universiti Sains Malaysia, Health Campus, Kubang Kerian Kota Bharu, Kelantan, 16150, Malaysia
- fDepartment of Engineering Materials and Mechanical Design, Faculty of Engineering, South Valley University, Qena, 83523, Egypt
- gSchool of Dentistry, University of Queensland, 288 Herston Road, Herston, QLD 4006, Australia
- hSchool of Medicine and Dentistry, Griffith University, Gold Coast Campus, Brisbane, QLD 4222, Australia
- iFaculty of Technical Sciences, University of Novi Sad, T. D. Obradovica 6, Novi Sad, 21000, Serbia
Abstract
Bone is a dynamic tissue that can always regenerate itself through remodeling to maintain biofunctionality. This tissue performs several vital physiological functions. However, bone scaffolds are required for critical-size damages and fractures, and these can be addressed by bone tissue engineering. Bone tissue engineering (BTE) has the potential to develop scaffolds for repairing critical-size damaged bone. BTE is a multidisciplinary engineered scaffold with the desired properties for repairing damaged bone tissue. Herein, we have provided an overview of the common carbohydrate polymers, fundamental structural, physicochemical, and biological properties, and fabrication techniques for bone tissue engineering. We also discussed advanced biofabrication strategies and provided the limitations and prospects by highlighting significant issues in bone tissue engineering. There are several review articles available on bone tissue engineering. However, we have provided a state-of-the-art review article that discussed recent progress and trends within the last 3-5 years by emphasizing challenges and future perspectives. © 2024 IOP Publishing Ltd. All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Indexed keywords
| Engineering controlled terms: | Biochemical engineeringCeramic materialsElastomersPhysiological modelsScaffolds (biology) |
|---|---|
| Engineering uncontrolled terms | BiofabricationBiofabrication strategyBiofunctionalityBone tissueBone tissue engineeringCarbohydrate polymersCritical sizeFundamental propertiesPhysiological functionsTissues engineerings |
| Engineering main heading: | Bone |
| EMTREE drug terms: | carbohydratepolymerpolysaccharidebiomaterialpolymer |
| EMTREE medical terms: | bone tissueceramicsdata miningelectric potentialhumannonhumanpharmaceuticsreviewtissue engineeringanimalbonebone prosthesisbone regenerationchemistrymetabolismprocedurestissue scaffold |
| MeSH: | AnimalsBiocompatible MaterialsBone and BonesBone RegenerationBone SubstitutesCarbohydratesCeramicsHumansPolymersTissue EngineeringTissue Scaffolds |
Chemicals and CAS Registry Numbers:
Biocompatible Materials; Bone Substitutes; Carbohydrates; Polymers
Funding details
| Funding sponsor | Funding number | Acronym |
|---|---|---|
| Horizon 2020 Framework Programme See opportunities by H2020 | 872370 | H2020 |
| Horizon 2020 Framework Programme See opportunities by H2020 | H2020 |
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We would like to thank the European Union\u2019s Horizon programme for partly supporting the research project. This project has received funding from the European Union\u2019s Horizon 2020 research and innovation program under Grant Agreement No. 872370.
- ISSN: 17486041
- Source Type: Journal
- Original language: English
- DOI: 10.1088/1748-605X/ad6b8a
- PubMed ID: 39105493
- Document Type: Review
- Publisher: Institute of Physics
Khan, M.U.A.; Department of Mechanical and Industrial Engineering, Qatar University, Doha, Qatar;
Abdullah, M.F.B.; Oral and Maxillofacial Surgery Unit, School of Dental Sciences Universiti Sains Malaysia, Health Campus, Kubang Kerian Kota Bharu, Kelantan, Malaysia;
© Copyright 2024 Elsevier B.V., All rights reserved.
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