Hydrogels: Classifications, fundamental properties, applications, and scopes in recent advances in tissue engineering and regenerative medicine – A comprehensive review(Review)(Open Access)
- aDepartment of Mechanical and Industrial Engineering, Qatar University, Doha, 2713, Qatar
- bBiomedical Research Center, Qatar University, Doha, 2713, Qatar
- cDepartment of Physics, University of Engineering of Engineering and Technology, Lahore, 39161, Pakistan
- dOral and Maxillofacial Surgery Unit, School of Dental Sciences, Universiti Sains Malaysia, Health Campus, 16150, Kubang Kerian, Kelantan, Kota Bharu, Malaysia
- eOral and Maxillofacial Surgery Unit, Hospital Universiti Sains Malaysia, Universiti Sains Malaysia, Health Campus, 16150, Kubang Kerian, Kelantan, Kota Bharu, Malaysia
- fDepartment of Chemistry, College of Science, King Faisal University, P.O. Box 400, Al-Ahsa, 31982, Saudi Arabia
- gDepartment of Electronics, Faculty of Technical Sciences, University of Novi Sad, Novi Sad, 21000, Serbia
Abstract
Hydrogels are three-dimensional structures that serve as substitutes for the extracellular matrix (ECM) and possess outstanding physicochemical and biochemical characteristics. They are gaining importance in regenerative medicine because of their similarity to the natural extracellular matrix in terms of moisture content and wound and tissue healing permeability. Tissue engineering advancements have resulted in the development of flexible hydrogels that mimic the dynamic characteristics of the ECM. Several approaches have been applied to produce hydrogels from biopolymers with enhanced functional and structural characteristics for different applications in tissue engineering and regenerative medicine (TERM). This review provides a comprehensive overview of hydrogel in wound healing, tissue engineering, and drug delivery systems. We outline different types of hydrogels based on the physical and chemical crosslinking, fundamental properties, and their applications in TERM. This review article provided the recent literature on hydrogels for tissue engineering and regenerative medicine within five years. Recent developments in biopolymer-based hydrogels for state-of-the-art tissue engineering and regenerative medicine have been discussed, emphasizing their significant challenges and future perspectives. © 2024
Indexed keywords
| Engineering controlled terms: | Controlled drug deliveryCrosslinkingRegenerative medicineTargeted drug deliveryTissue regeneration |
|---|---|
| Engineering uncontrolled terms | %moistureBiochemical characteristicsExtracellular matricesFundamental propertiesPhysicochemical characteristicsRegenerative medicineThree-dimensional structureTissue healingTissues engineeringsWound healing |
| Engineering main heading: | Tissue |
Funding details
| Funding sponsor | Funding number | Acronym |
|---|---|---|
| Horizon 2020 | ||
| Horizon 2020 Framework Programme See opportunities by H2020 | 872370 | H2020 |
| Horizon 2020 Framework Programme See opportunities by H2020 | H2020 |
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1
We would like to thank the European Union's Horizon programme for partly supporting the research project. This project has received funding from the European Union's Horizon 2020 Research and Innovation Program under grant agreement no. 872370.
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2
We would like to thank the European Union\u2019s Horizon programme for partly supporting the research project. This project has received funding from the European Union\u2019s Horizon 2020 Research and Innovation Program under grant agreement no. 872370.
- ISSN: 18785352
- Source Type: Journal
- Original language: English
- DOI: 10.1016/j.arabjc.2024.105968
- Document Type: Review
- Publisher: Elsevier B.V.
Khan, M.U.A.; Department of Mechanical and Industrial Engineering, Qatar University, Doha, Qatar;
© Copyright 2024 Elsevier B.V., All rights reserved.
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